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首页> 外文期刊>The Journal of Antibiotics: An International Journal >An aberrant metabolic flow toward early shunt products in the granaticin biosynthetic machinery of Streptomyces vietnamensis GIMV4.0001
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An aberrant metabolic flow toward early shunt products in the granaticin biosynthetic machinery of Streptomyces vietnamensis GIMV4.0001

机译：一种异常的代谢流向早期分流产品在麦芽肿越南的榴弹菌属BioSynthetic机械越南的Gimv4.0001

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摘要

A systematic study of the secondary metabolites of the wild granaticin-producing strain Streptomyces vietnamensis GIMV4.0001 led to the isolation of six known early shunt products related to actinorhodin, SEK34 (3), SEK34b (4), mutactin (5), dehydromutactin (7), EM18 (8) and GTRI-02 (9). While the other shunt products were minor or trace products, the production ratio of SEK34 (3) and SEK34b (4) to granaticins was strikingly high. Nearly 64% of the intermediate with the first ring closed went to the SEK34/SEK34b aberrant pathway. The high level of the aberrant metabolic flow toward the early shunt products SEK34 and SEK34b indicated that the second ring closure of the granaticin (1) biosynthesis is a key limiting step in the granaticin biosynthetic machinery of S. vietnamensis GIMV4.0001.
机译：野生榴素生成菌株的次生代谢物的系统研究Streptomyces越南盾Gimv4.0001导致了与Actinorhodin，SEK34（3），SEK34B（4），蛋白酶（5），脱氢丁蛋白（ 7），EM18（8）和GTRI-02（9）。 虽然其他分流产物是轻微或痕量产品，但SEK34（3）和SEK34B（4）的生产比率显着高。 第一环近64％的中间体闭合到SEK34 / SEK34B异常途径。 对早期分流产品SEK34和SEK34B的高水平的异常代谢流表明，榴芩苷（1）生物合成的第二个环闭合是S.越南的Gimv4.0001的麦芽蛋白生物合成机械的关键限制步骤。

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    Deng Ming-Rong; Li Yan; He Huang-Huang; Zhou Xiaoli; Zheng Xiang-Ling; Wang Yong-Hong; Zhu Honghui;

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    Guangdong Acad Sci Guangdong Microbial Culture Collect Ctr GDMCC State Key Lab Appl Microbiol;

    Guangdong Acad Sci Guangdong Microbial Culture Collect Ctr GDMCC State Key Lab Appl Microbiol;

    Guangdong Acad Sci Guangdong Microbial Culture Collect Ctr GDMCC State Key Lab Appl Microbiol;

    Guangdong Acad Sci Guangdong Microbial Culture Collect Ctr GDMCC State Key Lab Appl Microbiol;

    Guangdong Acad Sci Guangdong Microbial Culture Collect Ctr GDMCC State Key Lab Appl Microbiol;

    Guangdong Acad Sci Guangdong Microbial Culture Collect Ctr GDMCC State Key Lab Appl Microbiol;

    Guangdong Acad Sci Guangdong Microbial Culture Collect Ctr GDMCC State Key Lab Appl Microbiol;

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  • 正文语种 eng
  • 中图分类 药学;
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