A new antitrypanosomal alkaloid from the Red Sea marine sponge Hyrtios sp.

Shady Nourhan Hisham; Fouad Mostafa A.; Ahmed Safwat; Pimentel-Elardo Sheila Marie; Nodwell Justin R.; Kamel Mohamed Salah; Abdelmohsen Usama Ramadan

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A new antitrypanosomal alkaloid from the Red Sea marine sponge Hyrtios sp.

机译：来自红海海洋海绵Hyrtios SP的新的抗酸糖蛋白酶类化合物。

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The antitrypanosomally active crude extract of the sponge Hyrtios sp. was subjected to metabolomic analysis using liquid chromatography coupled with high resolution electrospray ionization mass spectrometry (LC-HR-ESIMS) for dereplication purposes. As a result, a new alkaloid, hyrtiodoline A (1), along with other four known compounds (2-5) were reported. The structures of compounds 1-5 were determined by spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESI-MS) experiments, as well as comparison to the literature. We further investigated the antitrypanosomal activity of the five compounds, where compound 1 exhibited the most potent antitrypanosomal activity, with a half-maximal inhibitory concentration (IC50) value of 7.48 mu M after 72 h.

机译：海绵Hyrtios sp的抗糖蛋白酶体粗提物。使用液相色谱法与高分辨率电喷雾电离质谱（LC-HR-ESIMS）偶联的代谢物分析进行全统一目的。结果，据报道，新的生物碱，HyrtiDoline A（1）以及其他四种已知的化合物（2-5）。通过光谱分析测定化合物1-5的结构，包括1D和2D核磁共振（NMR）和高分辨率电喷雾电离质谱（HRESI-MS）实验，以及与文献的比较。我们进一步研究了五种化合物的抗酸致韧带活性，其中化合物1表现出最有效的抗核糖体活性，其半最大抑制浓度（IC 50）值为72小时后7.48μm。

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《The Journal of Antibiotics: An International Journal》 |2018年第12期|共4页
作者
Shady Nourhan Hisham; Fouad Mostafa A.; Ahmed Safwat; Pimentel-Elardo Sheila Marie; Nodwell Justin R.; Kamel Mohamed Salah; Abdelmohsen Usama Ramadan;
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Deraya Univ Fac Pharm Dept Pharmacognosy POB 61111 New Minia City Minia Egypt;

Menia Univ Fac Pharm Dept Pharmacognosy Al Minya 61519 Egypt;

Suez Canal Univ Fac Pharm Dept Pharmacognosy Ismailia 41522 Egypt;

Univ Toronto MaRS Ctr West Dept Biochem 661 Univ Ave Toronto ON M5G 1M1 Canada;

Univ Toronto MaRS Ctr West Dept Biochem 661 Univ Ave Toronto ON M5G 1M1 Canada;

Deraya Univ Fac Pharm Dept Pharmacognosy POB 61111 New Minia City Minia Egypt;

Menia Univ Fac Pharm Dept Pharmacognosy Al Minya 61519 Egypt;

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正文语种 eng
中图分类药学;
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1. A new antitrypanosomal alkaloid from the Red Sea marine sponge Hyrtios sp. [J] . Shady Nourhan Hisham, Fouad Mostafa A., Ahmed Safwat, The Journal of Antibiotics: An International Journal . 2018,第12期

机译：来自红海海洋海绵Hyrtios SP的新的抗酸糖蛋白酶类化合物。
2. Hyrtinadines C and D, New Azepinoindole-Type Alkaloids from a Marine Sponge Hyrtios sp. [J] . Chemical and Pharmaceutical Bulletin . 2016,第7期

机译：Hyrtinadines C和D，来自海洋海绵Hyrtios sp。的新型Azepinoindole型生物碱。
3. Isolation, structure determination and cytotoxicity studies of tryptophan alkaloids from an Australian marine sponge Hyrtios sp. [J] . KhokharS., FengY., CampitelliM.R., Bioorganic and Medicinal Chemistry Letters . 2014,第15期

机译：澳大利亚海棉Hyrtios sp。色氨酸生物碱的分离，结构测定和细胞毒性研究。
4. Indole Alkaloids from South China Sea Marine Sponge Callyspongia sp. [C] . Bin Wang, Riming Huang, Yonghong Liu Information technology and agricultural engineering . 2011

机译：南海海洋海绵Callyspongia sp。的吲哚生物碱。
5. Studies on nitrogen-containing secondary metabolites from terrestrial and marine origin: Part I. Enzymatic epoxidation of 2,5-dihydroxyacetanilide in Streptomyces sp. Part II. Synthesis of marine sponge alkaloids: Slagenins, axinohydantoins, and studies towards the pyrrolopiperazine system in the agelastatin core. [D] . Barrios Sosa, Ana Carolina. 2002

机译：陆生和海洋来源的含氮次生代谢产物的研究：第一部分。链霉菌属中2,5-二羟基乙酰苯胺的酶促环氧化。第二部分海洋海绵生物碱的合成：Slagenins，Axinohydantoins，以及在astlastatin核心中对吡咯烷哌嗪系统的研究。
6. A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus [O] . Wayne D. Inman, Walter M. Bray, Nadine C. Gassner, -1

机译：一个β咔啉生物碱从巴布亚新几内亚海洋海绵Hyrtios网纹
7. Indole alkaloid from the Red Sea sponge Hyrtios erectus [O] . Mohamed A. Ashour, Ehab S. Elkhayat, Rainer Ebel, 2007

机译：来自红海海绵Hyrtios erectus的吲哚生物碱

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A new antitrypanosomal alkaloid from the Red Sea marine sponge Hyrtios sp.

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