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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Effect of Intravenous Oxycodone Versus Sufentanil on the Incidence of Postoperative Nausea and Vomiting in Patients Undergoing Gynecological Laparoscopic Surgery
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Effect of Intravenous Oxycodone Versus Sufentanil on the Incidence of Postoperative Nausea and Vomiting in Patients Undergoing Gynecological Laparoscopic Surgery

机译：静脉内羟酮对血管腹腔镜术后术后恶心发病率和呕吐的影响

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Abstract More than 30% of patients who undergo surgery will experience postoperative nausea and vomiting (PONV) if no prophylactic treatments are used. Although numerous studies have been performed to investigate the factors related to PONV, the effect of perioperative intravenous oxycodone on the incidence of PONV has not been well investigated. In this study, gynecological patients (grade I‐II, aged 18‐65 years, scheduled to undergo elective gynecological laparoscopic surgery under general anesthesia) were randomized to the oxycodone group or the sufentanil group. In the oxycodone group, patients received intravenous oxycodone for the induction and maintenance of anesthesia, as well as postoperative analgesia, while sufentanil was used in the sufentanil group. The primary outcome variable was the incidence of PONV. As secondary outcomes, time to first PONV, the rating of the most severe PONV, postoperative pain scores at different time points, hemodynamics, and side effects were evaluated. We found that, compared with sufentanil, oxycodone decreased the incidence of PONV by 13.5% ( P = .041). The time to first vomiting was longer in the oxycodone group than in the sufentanil group. Postoperative pain scores at different time points and hemodynamics were comparable between the oxycodone and sufentanil groups. We concluded that the incidence of PONV in gynecological patients who underwent laparoscopic surgery was lower when using intravenous oxycodone for anesthesia induction, anesthesia maintenance, and postoperative analgesia than when using intravenous sufentanil. However, oxycodone and sufentanil provided the same stable hemodynamics during surgery and satisfactory postoperative analgesia.
机译：摘要如果没有使用预防性处理，超过30％的患者将经历术后恶心和呕吐（PONV）。虽然已经进行了许多研究来研究与PONV有关的因素，但围手术期静脉内羟考酮对PONV发病率的影响尚未得到很好的研究。在这项研究中，妇科患者（18-65岁的等级I-II，计划在全身麻醉下进行选修妇科腹腔镜手术被随机化为羟考酮组或Sufentanil组。在羟考酮组中，患者接受静脉内羟考酮用于感应和维持麻醉，以及术后镇痛，而Sufentanil用于苏芬太尼。主要结果变量是PONV的发生率。作为二次结果，第一次PONV的时间，评价在不同时间点，血流动力学和副作用中最严重的PONV，术后疼痛评分和副作用。我们发现，与苏芬太尼相比，羟考酮减少了痘痘的发病率13.5％（P = .041）。首先呕吐的时间在羟考酮组中比在苏芬太尼群体中更长。在不同时间点和血流动力学的术后疼痛评分在羟考酮和苏芬太尼组之间具有可比性。我们得出结论，当使用静脉内羟考酮进行麻醉诱导，麻醉维持和术后镇痛时，腹腔镜手术的妇科患者的发病率降低而不是使用静脉内苏芬太尼。然而，在手术和令人满意的术后镇痛期间，羟考酮和苏芬太尼提供了相同的稳定血液动力学。

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