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首页> 外文期刊>The journal of clinical psychiatry >Pretreatment with Ibuprofen to prevent electroconvulsive therapy-induced headache.
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Pretreatment with Ibuprofen to prevent electroconvulsive therapy-induced headache.

机译：对布洛芬进行预处理，以防止电谐波治疗诱导的头痛。

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BACKGROUND: Although electroconvulsive therapy (ECT) has been widely recognized as an effective treatment for severe depression and various other psychiatric illnesses, adverse effects have been frequently reported, especially a high incidence of headache. Analgesics, such as acetaminophen, narcotics, or nonsteroidal anti-inflammatory drugs (NSAIDs), are commonly used to treat ECT-induced headache. The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT. METHOD: All inpatients on the psychiatric units who required ECT treatment were asked to participate in the study. Thirty-four patients were randomly assigned to receive either ibuprofen, 600 mg, or placebo orally 90 minutes prior to the initial ECT session, with the alternate treatment given for the second ECT treatment. Patients were asked to complete a questionnaire prior to and after the first 2 ECT treatments regarding the pattern, severity,and onset of headache. Severity of the headache was measured on a visual analogue scale (VAS). RESULTS: Ten patients experienced headache in neither treatment arm, while 7 patients experienced headache in both treatment arms. Eleven patients experienced headache with placebo but not with ibuprofen, while 2 patients experienced headache with ibuprofen but not with placebo. Ibuprofen was significantly more effective than placebo in preventing the onset of headache post-ECT (p =.022). The mean +/- SD VAS headache scores were 1.49 +/- 1.54 and 0.54 +/- 0.91 in the placebo and ibuprofen arms, respectively. Ibuprofen was significantly more effective than placebo in reducing the severity of ECT-induced headache (p =.007). CONCLUSION: Ibuprofen premedication reduced the frequency and severity of headache post-ECT and should be considered for appropriate patients who suffer from ECT-induced headache.
机译：背景：虽然静电疗法（ECT）被广泛认为是对严重抑郁症和各种其他精神疾病的有效治疗，但经常报道不良反应，尤其是头痛的高发病率。镇痛药，例如乙酰氨基酚，麻醉药或非甾体抗炎药（NSAIDs），通常用于治疗ECT诱导的头痛。本研究的目的是确定与布洛芬的预处理是否会阻止出现或减少ECT后发生的头痛的严重程度。方法：要求所有需要ECT治疗的精神病患者的住院患者参加该研究。随机分配34例患者，在初始ECT会话前90分钟在初始ECT会话前70分钟接收布洛芬，600mg或安慰剂，给予第二种ECT治疗。要求患者在前两种ECT治疗后和头痛的治疗前和头痛的术前完成调查问卷。在视觉模拟量表（VAS）上测量头痛的严重程度。结果：10名患者在任何治疗臂都经历过头痛，而7例患者在两种治疗臂都经历过头痛。 11名患者经历了安慰剂的头痛，但不适用于布洛芬，而2名患者与布洛芬有头痛，但不受安慰剂。在预防头痛后的发病时，布洛芬比安慰剂更有效（P = .022）。平均+/- SD VAS头痛评分分别为安慰剂和布洛芬武器中的1.49 +/- 1.54和0.54 +/- 0.91。在降低ECT引起的头痛的严重程度时，布洛芬比安慰剂更有效（P = .007）。结论：布洛芬预测降低了头痛后的频率和严重程度，应考虑患有ECT引起的头痛的适当患者。

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