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首页> 外文期刊>The journal of clinical psychiatry >Lithium combinations in acute and maintenance treatment of unipolar and bipolar depression.
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Lithium combinations in acute and maintenance treatment of unipolar and bipolar depression.

机译：单极和双相抑郁症急性和维持治疗锂组合。

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摘要

Bipolar illness and unipolar depression are both affective disorders associated with high lifetime morbidity and premature mortality due to suicide. Numerous double-blind, placebo-controlled trials have shown that lithium augmentation therapy is effective in treating acute episodes of bipolar depression, refractory major depression, and delusional depression as well as in reducing recurrences of these illnesses. Lithium is the only agent approved by the U.S. Food and Drug Administration for maintenance treatment of bipolar disorder. Further research is needed to specifically address whether the antidepressant effect of adding lithium is greater in bipolar disorder or in unipolar depressions. This article will summarize available evidence and clinical considerations regarding the use of lithium augmentation in acute and maintenance treatment of unipolar and bipolar depressions.
机译：双极性疾病和单极性抑郁症是由于自杀引起的高寿命发病率和过早死亡的情感障碍。 许多双盲，安慰剂对照试验表明，锂增强治疗可有效治疗双相抑郁，难治性重大抑郁和妄想抑郁症以及减少这些疾病的复发。 锂电是美国食品和药物管理局批准的双相障碍的唯一代理商。 需要进一步的研究来具体地解决添加锂的抗抑郁效果是否在双极性疾病或单极抑制中。 本文将总结有关使用锂增强在急性和维持治疗的术语和双极凹陷中的可用证据和临床考虑。

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