Phenoconversion of cytochrome P450 2D6: The need for identifying the intermediate metabolizer genotype

PreskornS.H.; BermE.J.J.; RisseladaA.J.; MulderH.; HakE.; WilffertB.

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Phenoconversion of cytochrome P450 2D6: The need for identifying the intermediate metabolizer genotype

机译：细胞色素p450 2d6的异种转化：需要鉴定中间代谢物基因型的需要

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Thank you for the opportunity to respond and thank Dr Berm and colleagues for their thoughtful and thought-provoking letter. My comments are solely from my perspective and do not necessarily reflect the views of my coauthors or the study sponsor as time did not permit a response from the entire group. I am gratified by the interest this article1 has generated and believe it is reflective of the importance of the topic and the study results. I do not disagree with the points raised in Dr Berm and colleagues' letter, which complements and extends points made in our article.

机译：感谢您有机会回复并感谢巴塞尔博士和同事的周到和思想挑衅的信。我的评论完全来自我的观点，而且随着时间的时间不允许响应整个集团的响应，不一定反映我的共同院胎或学习赞助商的意见。我对这款第1条产生并认为它反映了该专题的重要性以及研究结果的利益，我很满意。我并不不同意在博士和同事信中提出的积分，这补充了我们的文章中的积分。

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来源
《The journal of clinical psychiatry》 |2013年第10期|共1页
作者
PreskornS.H.; BermE.J.J.; RisseladaA.J.; MulderH.; HakE.; WilffertB.;
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作者单位

Department of Psychiatry Clinical Research Institute Wichita KS United States;

Department of Pharmacotherapy and Pharmaceutical Care University Center for Pharmacy University;

Clinical Pharmacy Wilhelmina Hospital Assen Assen Netherlands;

Clinical Pharmacy Wilhelmina Hospital Assen Assen Netherlands;

Department of PharmacoEpidemiology and PharmacoEconomics University Center for Pharmacy;

Department of Pharmacotherapy and Pharmaceutical Care University Center for Pharmacy University;

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正文语种 eng
中图分类精神病学;
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1. Phenoconversion of cytochrome P450 2D6: The need for identifying the intermediate metabolizer genotype [J] . PreskornS.H., BermE.J.J., RisseladaA.J., The journal of clinical psychiatry . 2013,第10期

机译：细胞色素P450 2D6的表位转化：需要鉴定中间代谢物基因型
2. Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response. [J] . Yadav SS, Ruwali M, Pant MC, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2010,第1a2期

机译：药物代谢细胞色素P450 2D6弱代谢者与细胞色素P450 2C9和2C19基因型的相互作用改变了对头颈癌的敏感性和治疗反应。
3. Human liver cytochrome P450 2D6 genotype, full-length messenger ribonucleic acid, and activity assessed with a novel cytochrome P450 2D6 substrate. [J] . McConnachie L, Bodor M, Kowdley K, Clinical Pharmacology and Therapeutics . 2004,第4期

机译：人肝细胞色素P450 2D6基因型，全长信使核糖核酸和活性用新型细胞色素P450 2D6底物评估。
4. In vivo cytochrome P450 drug metabolizing enzyme characterization using surface-enhanced Raman spectroscopy [C] . Yanfang Li, Kenneth A. Bachmann, Brent D. Cameron Society of Photo-Optical Instrumentation Engineers Conference on Genetically Engineered and Optical Probes for Biomedical Applications . 2003

机译：使用表面增强拉曼光谱法在体内细胞色素P450药物代谢酶表征
5. Docking and cheminformatic analysis of protein-ligand interactions: Cytochromes P450 (2D6 and P450cam) and estrogen receptors from human and zebrafish. [D] . Costache, Aurora Demetrina. 2006

机译：蛋白质-配体相互作用的对接和化学信息学分析：人类和斑马鱼的细胞色素P450（2D6和P450cam）和雌激素受体。
6. Increased risk of hospitalization for ultrarapid metabolizers of cytochrome P450 2D6 [O] . Paul Y Takahashi, Euijung Ryu, Jyotishman Pathak, 2017

机译：细胞色素P450 2D6超快速代谢者的住院风险增加
7. NEW CYTOCHROME P450 2D6*56 ALLELE IDENTIFIED BY GENOTYPE/PHENOTYPE ANALYSIS OF CRYOPRESERVED HUMAN HEPATOCYTES [O] . Li Li, Run-mei Pan, Todd D. Porter, 2006

机译：新型细胞色素p450 2D6 * 56用于冷冻保存的人肝细胞的基因型/表型分析鉴定

Phenoconversion of cytochrome P450 2D6: The need for identifying the intermediate metabolizer genotype

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