...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >The Safety of Duloxetine During Pregnancy and Lactation
【24h】

The Safety of Duloxetine During Pregnancy and Lactation

机译：妊娠与泌乳期间杜罗汀的安全性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Depression is common in women, especially during pregnancy and the postpartum period. Untreated depression is associated with many adverse gestational outcomes. It is therefore important to know about the safety of different antidepressant drugs during pregnancy and lactation so that informed decisions can be made regarding treatment. This article summarizes published literature on the subject with regard to duloxetine, an antidepressant with serotonin-norepinephrine reuptake inhibition properties. In general, it appears that the use of duloxetine during pregnancy is associated with an increase in the risk of spontaneous abortion, but no increase in other adverse outcomes, such as major fetal malformations. Late-pregnancy exposure to duloxetine may be associated with poor neonatal adaptation syndrome, but the magnitude of this risk is not known. Infant exposure to duloxetine in breast milk is less than 1% of the maternal weight-adjusted dose, suggesting that duloxetine can be safely administered to a woman who is breast-feeding her infant. In general, the very limited data available on the subject do not uncover a signal that the use of duloxetine during pregnancy or lactation increases the risk of adverse outcomes. (C) Copyright 2014 Physicians Postgraduate Press, Inc.
机译：抑郁症在女性中是常见的，特别是在怀孕期间和产后期间。未经处理的抑郁与许多不良妊娠期结果有关。因此，重要的是要知道在怀孕和哺乳期间不同抗抑郁药物的安全性，以便可以对治疗进行知情决策。本文总结了对Duloxetine的对象的出版文献，一种具有血清素 - 去甲肾上腺素再摄取性能的抗抑郁药。通常，似乎在妊娠期间使用杜罗汀与自发流产风险的增加有关，但其他不利结果没有增加，例如主要的胎儿畸形。妊娠晚期暴露于杜罗汀可能与新生儿适应综合征差，但这种风险的幅度尚不清楚。婴儿暴露于母乳中的硫罗汀的含量小于孕产妇体重调整剂量的1％，表明杜洛汀可以安全地给予母乳喂养婴儿的女性。通常，受试者上可获得的非常有限的数据不会揭示怀孕期间使用杜罗汀或哺乳期的信号增加了不良结果的风险。 （c）版权所有2014医师研究生媒体，Inc。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号