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首页> 外文期刊>The journal of clinical psychiatry >Depression predicts cognitive disorders in older primary care patients.
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Depression predicts cognitive disorders in older primary care patients.

机译：抑郁预测老年初级护理患者的认知障碍。

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OBJECTIVE: To investigate whether depression is independently associated with increased risk of incident dementia or cognitive disorder not otherwise specified (NOS) in an older primary care population. METHOD: This was a prospective 3-year cohort study of 470 patients aged >or= 65 years without baseline cognitive disorders who were recruited from primary care offices. Annual assessments completed from March 2003 through December 2005 included the use of the Structured Clinical Interview for DSM-IV to diagnose major depressive disorder (MDD) and minor depression (MinD) and the Hamilton Depression Rating Scale (HDRS) for depressive symptom severity. The Mini-Mental State Exam, Mattis Dementia Rating Scale-initiation/perseveration subscale, and the Trail Making Tests A and B informed diagnoses of dementia and cognitive disorder NOS. RESULTS: 36 subjects, representing a cumulative incidence of 13%, developed dementia or cognitive disorder NOS over 3 years. Using Cox proportional hazard survival models to calculate the risk ratio of depression for development of cognitive disorders, MDD and MinD (HR = 3.68; 95% CI, 2.1-6.42 and HR = 1.84; 95% CI, 1.05-3.21, respectively) and HDRS scores (HR = 1.07; 95% CI, 1.02-1.12) predicted new onset dementia or cognitive disorder NOS, when covarying age, gender, and education. CONCLUSIONS: Depressive disorders pose increased risk of incident dementia or cognitive disorder NOS in older primary care patients. Clinicians treating depressed older adults should monitor for development of cognitive disorders.
机译：目的：探讨抑郁症是否与未在较老的初级护理人口中未指定的入射痴呆或无法指定的认知疾病的风险较多。方法：这是一项潜在的3年队列研究，470名患者，= 65岁，没有基线认知障碍，他们被招募来自初级保健办公室。 2003年3月至2005年12月完成的年度评估包括利用DSM-IV的结构化临床面试，以诊断重大抑郁症（MDD）和轻微抑郁（思维）和汉密尔顿抑郁率（HDR）的抑郁症状严重程度。迷你精神状态考试，Mattis痴呆评级规模 - 启动/持久性分布，以及对痴呆症和认知疾病的诊断No.结果：36项受试者，代表累积发病率为13％，痴呆症或认知疾病3年超过3年。使用Cox比例危害存活模型来计算认知障碍，MDD和MIND抑郁症的风险比（HR = 3.68; 95％CI，2.1-6.42和HR = 1.84; 95％CI，1.05-3.21，1.05-3.21，1.05-3.21，1.05-3.21）和HDRS分数（HR = 1.07; 95％CI，1.02-1.12）预测新的发病性痴呆或认知疾病NOS，当心时代，性别和教育。结论：抑郁症造成较老初级护理患者入射痴呆或认知疾病NOS的风险。治疗抑郁症老年人的临床医生应监测认知障碍的发展。

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