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首页> 外文期刊>The journal of clinical psychiatry >How to Read a Research Paper: An Exercise in Critical Thinking in the Context of an Epidemiologic Study on Tamsulosin and the Risk of Dementia
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How to Read a Research Paper: An Exercise in Critical Thinking in the Context of an Epidemiologic Study on Tamsulosin and the Risk of Dementia

机译：如何阅读研究论文：在对杜夏植物的流行病学研究和痴呆风险的流行病学研究中的批判性思维中的练习

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A recent study of the relationship between tarnsulosin and dementia found that, in propensity score-matched analyses that adjusted for measured risk factors for dementia, the use of tamsulosin to treat benign prostatic hyperplasia (BPH) was associated with a small but significant increase in the risk of incident dementia relative to untreated BPH, BPH treated with the 50-reductase inhibitors dutasteride and finasteride, and BPH treated with the a adrenoceptor blockers doxazosin, terazosin, and alfuzosin. The choice of control groups addressed confounding by indication, confounding by disease severity, and confounding by pharmacologic drug class The authors of the study provided a wealth of detail in their main paper and in supplementary materials, allowing an almost forensic examination of the findings. This article discusses the study from the perspective of whether the hypothesis relating tamsulosin to dementia was set a priori or emerged after an exploratory exercise; whether tarnsulosin crosses the blood-brain barrier for dementia as the event of interest to be attributable to treatment; whether the action of tamsulosin is plausibly related to dementia as a possible outcome; whether confounding was adequately addressed in the analyses; whether the duration of follow-up was sufficient for the event of interest to be attributable to tamsulosin; whether the absolute increase in the rate of incident dementia was clinically significant; and what the curiosities in the dose-dependence and subgroup analysis findings could imply. These matters provide considerable food for thought Thus, this article is intended to serve as an example of how to read a paper critically and how to think about what the findings might suggest.
机译：最近关于塔枯索素和痴呆之间关系的研究发现，在调整痴呆症的测量危险因素的倾销匹配分析中，使用杜鹃花治疗良性前列腺增生（BPH）与较小但大幅增加有关入射痴呆的风险相对于未处理的BPH，用50-还原酶抑制剂治疗的BPH，用肾上腺素受体阻滞剂Doxazosin，Terazosin和Alfuzosin治疗BPH处理。对照组的选择通过征兆，通过疾病严重程度混淆，并通过药物药物课程的混淆，该研究的作者在他们的主要纸和补充材料中提供了丰富的细节，允许对调查结果几乎取证检查。本文从视角下讨论了该研究的假设是否与痴呆症相关的假设是在探索性运动后确定的或出现的;当感兴趣的情况下，Tarnsulosin是否越过痴呆症的血脑屏障; Tamsulosin的作用是否与痴呆症是可能的结果是合理的;在分析中是否充分解决了混杂;随访的持续时间是否足以使其归因于Tamsulosin;入射痴呆率的绝对增加是临床显着的;和剂量依赖性和亚组分析结果中的许可都可能意味着什么。这些问题为此提供了相当大的食物，因此本文旨在作为如何批判性地阅读论文的示例，以及如何考虑发现可能表明的内容。

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