Drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms due to lamotrigine differs from that due to other drugs

Tashiro Yasuya; Azukizawa Hiroaki; Asada Hideo; Niihara Hiroyuki; Morita Eishin; Yamauchi Teruo; Mizukawa Yoshiko; Kusakabe Yoshio; Numazawa Satoshi; Izumi Miki; Sueki Hirohiko; Watanabe Hideaki

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Drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms due to lamotrigine differs from that due to other drugs

机译：药物诱导的超敏反应综合征/药物反应与嗜酸性粒细胞和由于薄片引起的乳尖和全身症状因其他药物而异

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Abstract Drug‐induced hypersensitivity syndrome (DIHS), also referred to as drug reaction with eosinophilia and systemic symptoms (DRESS), is a multi‐organ systemic drug reaction characterized by hematological abnormalities and reactivation of human herpesvirus‐6 (HHV‐6). DIHS/DRESS is typically associated with a limited number of drugs, such as the anticonvulsants. Our group has treated 12 patients for DIHS/DRESS due to lamotrigine (LTG), but their presentation differed from that of patients with DIHS/DRESS caused by other drugs. The aim of the present study was to identify significant differences between DIHS/DRESS caused by LTG versus other drugs. We retrospectively reviewed data of 12 patients with DIHS/DRESS caused by LTG and 32 patients with DIHS/DRESS due to other drugs. The increase in alanine aminotransferase level was significantly milder in the LTG group than the DIHS/DRESS group due to other drugs. The percentage of atypical lymphocytes in the blood during DIHS/DRESS was lower in the LTG group. Serum levels of lactate dehydrogenase and thymus and activation‐regulated chemokine were also lower in the LTG group. There were fewer DIHS/DRESS patients with HHV‐6 reactivation in the LTG group than in the group treated with other drugs. Lymphocyte transformation after DIHS/DRESS onset was faster in the LTG group. The two groups did not differ with respect to the interval from first drug intake to rash, white blood cell count, blood eosinophilia or DRESS score. There were no significant histopathological differences between the two groups. The features of LTG‐associated DIHS/DRESS and DIHS/DRESS due to other drugs differ.

机译：摘要药物诱导的超敏反综合征（DIHS），也称为与嗜酸性粒细胞和全身症状（连衣裙）的药物反应，是一种具有血液学异常和人疱疹病毒-6（HHV-6）的再活化的多器官系统药物反应。 DIHS /衣服通常与有限数量的药物相关，例如抗惊厥药。由于乳草嗪（LTG），本集团对DIHS /连衣裙进行了治疗12名患者，但它们的介绍与其他药物引起的DIHS /服饰的患者不同。本研究的目的是鉴定由LTG与其他药物引起的DIHS /服饰之间的显着差异。我们回顾性地审查了由LTG和32例DIHS /连衣裙引起的DIHS /连衣裙的患者的数据进行了回顾性的，这是由于其他药物为主的DIHS /连衣裙。由于其他药物，LTG组丙氨酸氨基转移酶水平的增加显着较高。在LTG基团中，DIHS /衣服期间血液中的非典型淋巴细胞的百分比较低。 LTG基团中，血清乳酸脱氢酶和胸腺和活化调节的趋化因子也较低。 LTG组中有较少的DIHS /连衣裙患者HHV-6重新激活，而不是用其他药物处理的组。在LTG组中DIHS /衣服发作后淋巴细胞转化更快。这两组对来自第一药物摄入量的间隔没有不同于皮疹，白细胞计数，血液咽害或衣服评分。两组之间没有显着的组织病理学差异。由于其他药物引起的LTG相关DIHS /连衣裙和DIHS /连衣裙的特征不同。

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来源
《The Journal of dermatology》 |2019年第3期|共8页
作者
Tashiro Yasuya; Azukizawa Hiroaki; Asada Hideo; Niihara Hiroyuki; Morita Eishin; Yamauchi Teruo; Mizukawa Yoshiko; Kusakabe Yoshio; Numazawa Satoshi; Izumi Miki; Sueki Hirohiko; Watanabe Hideaki;
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作者单位

Department of DermatologyShowa University School of MedicineTokyo Japan;

Department of DermatologyNara Medical University School of MedicineNara Japan;

Department of DermatologyNara Medical University School of MedicineNara Japan;

Department of DermatologyShimane University Faculty of MedicineIzumo Japan;

Department of DermatologyShimane University Faculty of MedicineIzumo Japan;

Department of DermatologyShowa University School of MedicineTokyo Japan;

Department of DermatologyKyorin University School of MedicineTokyo Japan;

Faculty of Pharma‐SciencesTeikyo UniversityTokyo Japan;

Division of ToxicologyShowa UniversityTokyo Japan;

Department of Medical EducationShowa University School of MedicineTokyo Japan;

Department of DermatologyShowa University School of MedicineTokyo Japan;

Department of DermatologyShowa University School of MedicineTokyo Japan;

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原文格式 PDF
正文语种 eng
中图分类皮肤病学与性病学;
关键词
drug reaction with eosinophilia and systemic symptoms; drug‐induced hypersensitivity syndrome; human herpes virus 6; lamotrigine; thymus and activation‐regulated chemokine;

机译：药物反应与嗜酸性粒细胞和全身症状;药物诱导的过敏综合征;人疱疹病毒6;乳嗪;胸腺和激活调节的趋化因子;

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1. Drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms due to lamotrigine differs from that due to other drugs [J] . Tashiro Yasuya, Azukizawa Hiroaki, Asada Hideo, The Journal of dermatology . 2019,第3期

机译：药物诱导的超敏反应综合征/药物反应与嗜酸性粒细胞和由于薄片引起的乳尖和全身症状因其他药物而异
2. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms syndrome induced by cilostazol and carbamazepine [J] . KangS.-Y., KimJ.-Y., KimM.-Y., The Journal of dermatology . 2012,第8期

机译：西洛他唑和卡马西平引起的药物引起的过敏性综合征/嗜酸性粒细胞增多和全身症状综合征的药物反应
3. Drug-induced hypersensitivity syndrome: drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by aspirin treatment of Kawasaki disease. [J] . Kawakami T, Fujita A, Takeuchi S, Journal of the American Academy of Dermatology . 2009,第1期

机译：药物性超敏反应综合征：阿司匹林治疗川崎病引起的嗜酸性粒细胞增多和全身症状（DRESS）综合征的药物反应。
4. Discovering Drug-Drug Interactions and Associated Adverse Drug Reactions with Triad Prediction in Heterogeneous Healthcare Networks [C] . Haodong Yang, Christopher C. Yang IEEE International Conference on Healthcare Informatics . 2016

机译：在异类医疗网络中发现药物相互作用以及与三联征预测相关的不良药物反应
5. Involvement of Th17 Pathway in Adverse Drug Reactions: Mechanistic Investigation of Drug-Induced Autoimmunity and Drug-induced Liver Injury. [D] . Zhu, Ervin Xu. 2012

机译：Th17途径参与药物不良反应：药物诱发的自身免疫和药物诱发的肝损伤的机制研究。
6. Case Report: Aggressive treatment in paediatric or young patients with drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is associated with future development of type III polyglandular autoimmune syndrome [O] . Chiyo Morita, Tetsuji Yanase, Tetsuo Shiohara, 2018

机译：病例报告：小儿或青年患者药物性超敏反应综合征（DiHS）/嗜酸性粒细胞增多和全身症状药物反应（DRESS）的积极治疗与III型多腺自身免疫综合征的发展有关
7. Immune reconstitution inflammatory syndrome observed in the setting of drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) [O] . Yoko Kano, Yukiko Ushigome, Chiho Horie, 2014

机译：在药物诱发的过敏性综合征/药物反应伴嗜酸性粒细胞增多和全身症状的情况下观察到的免疫重建炎症综合症（DIHS / DRESS）

Drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms due to lamotrigine differs from that due to other drugs

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