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首页> 外文期刊>The Journal of dermatology >Effectiveness of topical propranolol 4% gel in the treatment of pyogenic granuloma in children
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Effectiveness of topical propranolol 4% gel in the treatment of pyogenic granuloma in children

机译：局部普萘洛尔4％凝胶治疗儿童化脓性肉芽肿的有效性

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Abstract Pyogenic granuloma is a benign acquired vascular tumor that affects the skin and mucous membranes, occurring more often in children and young adults. Treatment is often required due to the associated risk of ulceration and bleeding. There are several publications reporting the use of beta‐blockers for the treatment of pyogenic granuloma. The aim of the present study was to evaluate the clinical effectiveness and safety profile of topical propranolol 4% gel for the treatment of pyogenic granuloma. A retrospective study of all cases of pyogenic granuloma treated with topical propranolol 4% gel between 2014 and 2015 was performed. Epidemiological, clinical and treatment data, including effectiveness score and safety, were reviewed. Of a total of 18 patients with pyogenic granuloma, 11 (61.1%) showed complete resolution of the lesion while two (11.1%) had an almost complete response. In three cases (16.6%), the treatment was discontinued due to bleeding, and the lesions were removed by curettage. Local irritation and lack of compliance led to treatment discontinuation in two cases. Altogether, 13 out of 18 patients (72%) had complete or almost complete response to treatment. There was a correlation between treatment duration and response to treatment. One patient only reported local side‐effects including irritation, redness and scaling of the treated area leading to discontinuation of the treatment and curettage of the pyogenic granuloma. No systemic adverse effects were reported. This is an uncontrolled retrospective study. Propranolol 4% gel may be considered as a safe and efficient topical therapy for pyogenic granuloma.
机译：摘要化脓性肉芽肿是一种良性获得的血管肿瘤，影响皮肤和粘膜，在儿童和年轻的成年人中更常见。由于溃疡和出血的风险，通常需要治疗。有几种出版物报告使用β-阻滞剂用于治疗化脓性肉芽肿。本研究的目的是评估局部普萘洛尔4％凝胶的临床效果和安全性，用于治疗脓性肉芽肿。进行了对2014年至2015年间局部丙烯醇4％凝胶处理的所有胶质肉芽肿的回顾性研究。综述了流行病学，临床和治疗数据，包括有效性得分和安全性。总共18名脓性肉芽肿，11例（61.1％）显示出病变的完全分辨率，而两种（11.1％）几乎完全响应。在三种情况下（16.6％），由于出血，治疗已停止，并且通过刮宫除去病变。局部刺激和缺乏合规导致治疗在两种情况下停药。共有18名患者中的13名（72％）已经完全或几乎完全响应治疗。治疗持续时间与治疗反应之间存在相关性。一名患者仅报告了局部副作用，包括治疗区域的刺激，发红和缩放，导致脓泡肉芽肿的治疗和刮宫停止。没有报道全身不良反应。这是一个不受控制的回顾性研究。普萘洛尔4％凝胶可被认为是一种安全有效的术语术语肉芽肿。

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