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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Role of velamentous cord insertion in monochorionic twin pregnancies: a PRISMA-compliant systematic review and meta-analysis of observational studies
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Role of velamentous cord insertion in monochorionic twin pregnancies: a PRISMA-compliant systematic review and meta-analysis of observational studies

机译:无线电线插入在单体化双胞胎妊娠中的作用:符合Prisma的系统评价和荟萃分析观察研究

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摘要

Background: Velamentous cord insertion (VCI) has been proposed to be associated with some specific complications among monochorionic (MC) twin pregnancies. This meta-analysis and systematic review aims to determine the role of VCI in MC twin pregnancies. Methods: The PubMed, Embase and Web of Science databases and reference lists were searched for relevant studies. Outcomes of interest included twin-to-twin transfusion syndrome (TTTS), birthweight discordance (BWD) and selective intrauterine growth restriction (sIUGR). The methodological quality of the included studies was assessed by using the Newcastle-Ottawa Scale. The pooled results were calculated by means of a random or fixed effect model to obtain odds ratio with 95% confidential interval (CI). Subgroup analyses were utilized to detect the sources of heterogeneity. Results: Twenty studies were eligible for inclusion. The pooled result suggested a significant association between VCI and TTTS (OR, 1.542; 95% CI, 1.116-2.129) with a moderate level of heterogeneity (Q test: p = .024; I-2 = 50.2%). Subgroup analysis reported single-center study, methodological quality and exclusion of laser-coagulated TTTS as the sources of heterogeneity. Another analysis revealed an increased risk of BWD among twin pregnancies with VCI (OR, 2.945; 95% CI, 2.176-3.984) with a low heterogeneity (Q test: p = .347; I-2 = 10.5%). None of study level characteristics was found to be an influencing factor. Three studies reporting on sIUGR suggested a significant association between VCI and sIUGR. Conclusions: The meta-analysis and systematic review suggests an association between VCI and BWD and sIUGR. However, the association between VCI and TTTS may be overestimated and high-quality studies with a representative sample are needed in further research.
机译:背景:已经提出了Velamentod帘线插入(VCI)与单种(MC)双胞胎妊娠的一些特定并发症相关。该荟萃分析和系统综述旨在确定VCI在MC TWIN怀孕中的作用。方法:搜查了有关研究的PubMed,Embase和Sence数据库和参考列表。感兴趣的结果包括双对双输血综合征(TTTS),出生重量轻型(BWD)和选择性宫内生长限制(SIUGR)。通过使用纽卡斯尔 - 渥太华规模评估包括研究的方法论质量。通过随机或固定效果模型计算汇总结果,以获得95%机密间隔(CI)的差距。利用亚组分析来检测异质性的来源。结果:二十项研究有资格包涵式。汇总结果表明VCI和TTTS(或1.542; 95%CI,1.116-2.129)之间的显着关联,具有中等程度的异质性(Q测试:P = .024; I-2 = 50.2%)。亚组分析报道单中心研究,方法质量和激光凝固的TTT的排除作为异质性的来源。另一个分析显示,具有低异质性的VCI(或2.945%CI,2.176-3.984)的双胞胎妊娠的BWD风险增加(Q测试:P = .347; I-2 = 10.5%)。没有发现研究水平特征是影响因素。 SIUGR的三项研究表明VCI和SIUGR之间的重要关联。结论:META分析和系统审查表明VCI和BWD和SIUGR之间的关联。然而,VCI和TTT之间的关联可能被高估,并且在进一步的研究中需要具有代表性样本的高质量研究。

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  • 作者单位

    Southern Med Univ Foshan Inst Fetal Med Affiliated Maternal &

    Child Hlth Hosp Foshan 11 Renminxi;

    Southern Med Univ Foshan Inst Fetal Med Affiliated Maternal &

    Child Hlth Hosp Foshan 11 Renminxi;

    Southern Med Univ Foshan Inst Fetal Med Affiliated Maternal &

    Child Hlth Hosp Foshan 11 Renminxi;

    Southern Med Univ Foshan Inst Fetal Med Affiliated Maternal &

    Child Hlth Hosp Foshan 11 Renminxi;

    Southern Med Univ Foshan Inst Fetal Med Affiliated Maternal &

    Child Hlth Hosp Foshan 11 Renminxi;

    Southern Med Univ Dept Obstet Affiliated Maternal &

    Child Hlth Hosp Foshan Foshan Peoples R;

    Southern Med Univ Dept Obstet Affiliated Maternal &

    Child Hlth Hosp Foshan Foshan Peoples R;

    Southern Med Univ Foshan Inst Fetal Med Affiliated Maternal &

    Child Hlth Hosp Foshan 11 Renminxi;

    Southern Med Univ Dept Obstet Affiliated Maternal &

    Child Hlth Hosp Foshan Foshan Peoples R;

    Southern Med Univ Dept Obstet Affiliated Maternal &

    Child Hlth Hosp Foshan Foshan Peoples R;

    Southern Med Univ Foshan Inst Fetal Med Affiliated Maternal &

    Child Hlth Hosp Foshan 11 Renminxi;

    Southern Med Univ Foshan Inst Fetal Med Affiliated Maternal &

    Child Hlth Hosp Foshan 11 Renminxi;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 产科学;
  • 关键词

    Birthweight discordance; meta-analysis; selective intrauterine growth restriction; twin-to-twin transfusion syndrome; velamentous cord insertion;

    机译:诞生重量轻视;荟萃分析;选择性宫内生长限制;双对转体输血综合征;旋转丝网插入;

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