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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Are low birth weight children predisposed to renal loss of carnitine?
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Are low birth weight children predisposed to renal loss of carnitine?

机译：是低出生体重儿，令人生畏的肉毒碱损失吗？

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Aim:The plasma homeostasis of both free and esterified carnitines is mostly regulated by renal tubular reabsorption, which may be disturbed in low birth weight children. The aim of study was to check whether disturbances in excretion ofl-carnitine (LC) and its main ester, acetyl-carnitine (ALC), may be the result of renal dysfunction in low birth weight children (LBW). Methods:This study included 59 LBW children (2165 g [1490-2440]) and 22 children with normal birth weight as a reference group (3500 g [3275-3650]). Subjects were divided into three groups: 0-3 months, 4-12 months and over 1 year at the time of testing. Urinary levels of carnitine were measured spectrophotometrically. Results:The urine excretion of Free LC, Free LC/cr, Total LC and Total LC/cr. Were significantly higher in 0-3 and 4-12-month old LBW infants study groups when compared to the reference groups. We found statistically significant higher urine excretion of ALC and ALC/cr. in all age groups of LBW infants compared to the reference group. There was a negative correlation between birth weight and free LC/cr. (r= -0.3,p 12-month-old strong negative correlation between eGFR and free LC/cr. (r= -0.6,p < .05), Total LC/cr. (r= -0.61,p < .05), ALC/cr. (r= -0.61,p < .05.) Conclusion:Higher urine excretion of both LC and ALC and its negative correlation with birth weight and eGFR may reflect some degree of renal dysfunction in LBW infants.
机译：目的：自由和酯化肉毒碱的血浆稳态主要受肾小管重吸收的调节，这可能在低出生体重儿中受到干扰。研究的目的是检查排泄中的肉毒碱（LC）及其主要酯，乙酰基肉碱（ALC）的紊乱是否可以是低出生体重儿童（LBW）中肾功能不全的结果。方法：本研究包括59名LBW儿童（2165克[1490-2440]）和22例患有正常出生体重作为参考组的儿童（3500克[3275-3650]）。受试者分为三组：0-3个月，4-12个月和1年在测试时。分光光度法测量尿素的尿液水平。结果：游离LC，游离LC / Cr，总LC和总LC / Cr的尿液排泄。与参考组相比，0-3和4-12个月的LBW婴儿研究组在0-3和4-12个月的幼儿研究组。我们发现ALC和ALC / Cr的统计学显着的尿液排泄。在所有年龄的LBW婴儿组中与参考组相比。出生体重和免费LC / Cr之间存在负相关性。 （r = -0.3，p 12个月历史的EGFR和免费LC / Cr之间的强度负相关。（r = -0.6，p <.05），总LC / Cr。（r = -0.61，p <.05 ），ALC / Cr。（r = -0.61，p <.05。）结论：LC和ALC的尿液较高，与出生体重和EGFR的负相关可能反映LBW婴儿的一定程度的肾功能障碍。

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