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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >A comparison of the effects of invasive mechanic ventilation/surfactant therapy and non-invasive nasal-continuous positive airway pressure in preterm newborns
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A comparison of the effects of invasive mechanic ventilation/surfactant therapy and non-invasive nasal-continuous positive airway pressure in preterm newborns

机译：侵入力通风/表面活性剂治疗和非侵入性鼻连续正气道压力在早产新生儿影响的比较

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Aims: This study compared the early-term outcomes of mechanical ventilation (MV)/surfactant treatment with nasal-continuous positive airway pressure (nCPAP) in preterm infants with respiratory distress syndrome (RDS).Materials and methods: Data from newborns born between 24 and 32 weeks of gestation, hospitalized at our newborn intensive care unit, and diagnosed with RDS between January 2009 and February 2012 were analyzed.Results: Of 193 newborns with RDS who were enrolled in the study, 113 were treated with nCPAP and 80 with MV at a level of 57.5% of nCPAP. Within the study group, 46.3% of the infants were female. The mean gestation of the continuous positive airway pressure (CPAP) group was 29.071.99 weeks; that of the MV group was 28.61 +/- 2.01 weeks. The birth weight was 1321.1 +/- 325.4g and 1240.3 +/- 366.1g; however, the difference between the two groups was not significant. MV was not required in 54.9% of the patients with nCPAP treatment. Bronchopulmonary dysplasia (BPD) developed in 20 (18.7%) patients in the nCPAP group and 18 (24.4%) patients in the MV group; the difference was not significant (p=.351). Between 2009 and 2012, nCPAP was used at a rate of 33.9, 70.8, 68.4, and 69%. The risk factors for developing BPD were low gestation week, duration of intubation, and proven sepsis (p=.0001, p=.004, and p=.011, respectively).Conclusions: Early nCPAP treatment in preterm infants (32 weeks of gestation) decreases both the need for MV and the use of surfactant, but without a significant effect on BPD development. (No. 2016/324)
机译：目的：本研究比较了使用呼吸窘迫综合征（RDS）的早产儿鼻连续正气道压力（NCPAP）的机械通风（MV）/表面活性剂治疗的早期结果（NCPAP）。材料和方法：来自24的新生儿的数据在我们的新生重症监护手册中住院，在2009年1月至2012年1月至2012年2月诊断出来的妊娠32周。结果：193名与RDS的新生儿在研究中，113人被NCPAP和80次治疗在NCPAP的57.5％的水平。在研究组中，46.3％的婴儿是女性。连续正气道压力（CPAP）组的平均掩盖为29.071.99周; MV组的MV +/- 2.01周为28.61 +。出生体重是1321.1 +/- 325.4g和1240.3 +/- 366.1g;然而，两组之间的差异并不重要。在54.9％的NCPAP治疗患者中不需要MV。在NCPAP组的20名（18.7％）患者中开发的支气管扩漏性发育不良（BPD）和MV组中的18例（24.4％）患者;差异不显着（p = .351）。在2009年至2012年间，NCPAP以33.9,70.8,68.4和69％的速度使用。开发BPD的危险因素是低妊娠周，插管持续时间，并经过验证的败血症（P = .0001，P = .004，P = .011）。结论：早期NCPAP治疗早产儿（32周妊娠）降低了对MV的需求和表面活性剂的使用，但对BPD发育没有显着影响。 （第2016/324号）

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