...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Maternal side effects & fetal neuroprotection according to body mass index after magnesium sulfate in a multicenter randomized controlled trial
【24h】

Maternal side effects & fetal neuroprotection according to body mass index after magnesium sulfate in a multicenter randomized controlled trial

机译：母体副作用和胎儿神经保护根据体重指数在多中心随机对照试验中的硫酸镁后

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Evidence supports the need of dose-adjustment of several drugs according to body mass index (BMI) to prevent toxicity in the underweight, and ensure efficacy in obese women. However, for MgSO4 neuroprotection, the effect of BMI on maternal toxicity and fetal neuroprotection is understudied. We analyze the effect of BMI on maternal/infant outcomes after MgSO4.Methods: Secondary analysis of a clinical trial that studied MgSO4 neuroprotection. Maternal side effects, magnesium cord levels, and offspring cerebral palsy/death were analyzed along BMI strata using ANOVA and chi-square test. Logistic regression was used to calculate adjusted odds ratios according to the treatment and BMI, using nonobese that received placebo as reference. Interaction analyses were performed to validate differential efficacy of BMI.Results: From 2241 women, more side effects and higher magnesium cord levels were seen in underweight women (p=0.05). MgSO4 neuroprotection was effective in the non-obese (p=0.02), but not in obese women (p=1.00). In multivariate analyses, MgSO4 significantly reduced cerebral palsy only in nonobese women. Interaction analyses showed the moderator effect of BMI (p=0.169). Increasing MgSO4 dose in obese mothers may ensure neuroprotective efficacy without representing increased maternal risks. Considering costs of studying this association, current analysis may form the basis for reasonable practice.
机译：目的：证据支持根据体重指数（BMI）的多种药物剂量调整需要治疗多重药物的需求，以防止体重体内的毒性，并确保肥胖妇女的疗效。然而，对于MgSO 4神经保护作用，BMI对母体毒性和胎儿神经保护作用的影响被抑制。我们分析了BMI对MgSO4后母婴孕产的影响。方法：研究MgSO4神经保护作用的临床试验的二次分析。使用ANOVA和Chi-Square试验沿BMI地层分析母副作用，镁帘线水平和后代脑瘫/死亡。使用非obese作为参考，使用逻辑回归来计算根据治疗和BMI的调整后的差距比率。进行相互作用分析以验证BMI的差异疗效。结果：从2241名女性中，体重女性中观察到更高的副作用和更高的镁帘线水平（P = 0.05）。 MgSO4神经保护在非肥胖（P = 0.02）中有效，但不在肥胖女性（P = 1.00）中。在多变量分析中，MgSO4仅在非妇女中显着降低了脑瘫。相互作用分析显示BMI的主持人效应（P = 0.169）。肥胖母亲的MgSO4剂量增加可能会确保神经保护效果而不代表母体风险。考虑到学习本协会的成本，目前的分析可以构成合理实践的基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号