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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Neonatal uterine bleeding as a biomarker for reproductive disorders during adolescence: a worldwide call for systematic registration by nurse midwife
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Neonatal uterine bleeding as a biomarker for reproductive disorders during adolescence: a worldwide call for systematic registration by nurse midwife

机译：新生儿子宫子宫作为青春期生殖障碍的生物标志物：护士助产士的全球呼吁系统登记

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Neonatal uterine bleeding (NUB) occurs in approximately 5% of newborns and is generally considered to be of little clinical significance. However, the real clinical importance of this condition and its long-term implications remain to be determined. The reason why NUB is rare despite high circulating levels of progesterone can be attributed to a progesterone resistance present in a majority of neonates. Recent work indicates that NUB represents a significant biomarker for events that can occur later-on during adolescence. Indeed, clinical studies have shown that neonatal menstruation constitutes a sign of fetal distress during late pregnancy, reflecting a stage of endometrium development that may subsequently have an impact on the reproductive life of the adolescent and the young adult. Via retrograde flow, NUB can cause endometrial stem/progenitor cells to arrive into the pelvic cavity and survive there, dormant underneath the peritoneal surface, until menarche activates them. Indeed, there is both clinical and epidemiological evidence of a link between NUB and adolescent endometriosis. In addition, if progesterone resistance persists till the onset of menarche, in case of an early teen pregnancy, it can result in a disorder of deep placentation. Therefore, we propose that NUB should be carefully recorded so that prospective studies can examine its links with reproductive disorders in adolescence and beyond.
机译：新生儿子宫子宫出血（NUB）发生在大约5％的新生儿中，并且通常被认为是几乎没有临床意义。然而，仍有待确定这种情况的真正临床重要性及其长期影响。尽管Nub罕见的原因尽管普通猪矿石高循环水平，其归因于大多数新生儿中存在的孕酮抗性。最近的工作表明，Nub代表了在青春期期间可以发生的事件的重要生物标志物。实际上，临床研究表明，新生儿月经在怀孕后的胎儿窘迫迹象，反映了子宫内膜发育的阶段，随后可能对青少年和年轻成年人的生殖生活产生影响。通过逆行流动，NUB可以导致子宫内膜茎/祖细胞到达骨盆腔并在那里存活，腹膜表面下面的休眠，直到初潮激活它们。实际上，临床和流行病学证据表明NUB和青春期内膜异位症之间的联系。此外，如果孕酮抵抗持续到初始孕期的发作，如果早期怀孕，它可能导致沉默的紊乱。因此，我们建议仔细记录NUB，使得前瞻性研究可以检查其与青春期和超越的生殖障碍的联系。

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