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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Angiogenic imbalance as a contributor to the pathophysiology of preeclampsia among black African women
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Angiogenic imbalance as a contributor to the pathophysiology of preeclampsia among black African women

机译：血管生成不平衡作为黑色非洲妇女前普拉克西亚病理生理学的贡献者

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Objective: The pathogenesis of preeclampsia remains unclear despite extensive research. Altered angiogenic balance has been hypothesized to play a significant role in the clinical manifestations of this syndrome. However this imbalance has not been investigated extensively among black African women. The aim of this study was to investigate the maternal levels of the angiogenic factors soluble vascular endothelial growth factor receptor 1 (sFLT1) and placental growth factor (PlGF) among black African women with preeclampsia.Methods: A case control study was conducted in the Mthatha hospital complex in South Africa including 51 women with preeclampsia and 82 women with uncomplicated pregnancies. Blood samples were drawn from participants and serum was used to assess sFLT1, and PlGF levels quantified using specific enzyme linked immunosorbent assays. Non- parametric statistics were used for analysis.Results: Black African women with preeclampsia were found to have significantly lower levels of PlGF (90.38.9pg/ml versus 172.8 +/- 20.2pg/ml; p<0.01), higher sFLT1 (2087.3 +/- 200.1pg/ml versus 1546.5 +/- 91.9pg/ml; p<0.01) and a higher sFLT1/PIGF ratio (66.8 +/- 18.7 versus 22.3 +/- 2.9; p<0.01) compared to black African normotensive controls.Conclusion: The results support an altered angiogenic balance may contribute to the pathogenesis/pathophysiology of preeclampsia among black African women as reported in other populations.
机译：目的：虽然研究广泛，但预普拉姆证调的发病机制仍不清楚。已被改变的血管生成平衡已经假设在该综合征的临床表现中起着重要作用。然而，这种不平衡尚未在黑色非洲妇女中进行广泛调查。本研究的目的是探讨血管生成因子可溶性血管内皮生长因子受体1（SFLT1）和胎盘生长因子（PLGF）的母体水平，BELECLAMPSIA。方法：在MTHANA进行案例对照研究南非医院综合体包括51名妇女患有先兆子痫和82名妇女，具有简单的怀孕。从参与者中抽取血样，使用血清评估SFLT1，并使用特异性酶联免疫吸附测定来定量PLGF水平。非参数统计用于分析。结果：发现具有先兆子痫的黑人非洲妇女较低的PLGF水平较低（90.38.9pg / ml与172.8 +/- 20.2pg / ml; p <0.01），更高的SFLT1（2087.3 +/- 200.1pg / ml与1546.5 +/- 91.9pg / ml; p <0.01）和较高的SFLT1 / PIGF比率（66.8 +/- 18.7与22.3 +/- 2.9; p <0.01）相比，与黑色非洲正规符相比对照。结论：结果支持改变的血管生成平衡可能有助于在其他人口中报道的黑色非洲妇女中预坦克西亚的发病机制/病理生理学。

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