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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Deterioration/relapse of depression during pregnancy in Japanese women associated with interruption of antidepressant medications
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Deterioration/relapse of depression during pregnancy in Japanese women associated with interruption of antidepressant medications

机译：与抗抑郁药中断相关的日本女性怀孕期间抑郁症的恶化/复发

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摘要

This study examined the risk of deterioration/relapse in pregnant women who discontinued their antidepressant medications based on the discretion of the psychiatric specialists compared with those who performed self-interruption. We reviewed the obstetric records of all singleton deliveries beyond 22 weeks of gestation at Japanese Red Cross Katsushika Maternity Hospital from January 2009 through December 2015. Compared with the women continuing antidepressant medications throughout pregnancy, the incidence of deterioration/relapse was higher in the women who discontinued their antidepressant medications regardless of who made the decision (interruption based on the discretion of the psychiatric specialists: 61%, odds ratio (OR), 8.05; 95% confidence interval (CI), 2.4-27; p<0.01; self-interruption: 63%, odds ratio (OR), 8.79; 95% confidence interval (CI), 2.6-29; p<0.01 versus 16%). The continuation of medications and careful observation are required for pregnant women complicated by depressive disorders.
机译：本研究检测了孕妇的恶化/复发的风险，他们根据精神科专家的自由裁量与进行自我中断的人相比，这些孕妇停止了抗抑郁药物。我们审查了2009年1月至2015年12月在日本红十字会Katsushika产妇医院妊娠超过22周内的所有单例交付的产科记录。与在整个怀孕期间继续抗抑郁药物的女性相比，妇女的恶化/复发的发生率更高无论谁作出决定，终止了他们的抗抑郁药物（基于精神科专家的判断中断：61％，赔率比（或），8.05; 95％置信区间（CI），2.4-27; P <0.01;自我中断：63％，差距（或），8.79; 95％置信区间（CI），2.6-29; P <0.01与16％）。患有抑郁症复杂的孕妇需要延续药物和仔细观察。

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