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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Maternal plasma cholesterol concentration and preterm birth: a meta-analysis and systematic review of literature
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Maternal plasma cholesterol concentration and preterm birth: a meta-analysis and systematic review of literature

机译：母体血浆胆固醇浓度和早产：荟萃分析和系统审查

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Background: Women that previously had preterm labor are at an increased risk for heart disease. Because spontaneous preterm birth is an adverse pregnancy outcome that affects millions of children worldwide, our objective was to review and analyze studies that have examined associations between maternal total cholesterol (TC), LDL-C, and HDL-C concentrations during pregnancy and the risk of preterm birth to potentially define biomarkers or targets for treatment. Method: A search was performed and 22 articles were found that examined the association of maternal plasma cholesterol concentrations and preterm birth. A meta-analysis was performed on 10 of the articles, those that used maternal lipid concentrations as the outcome and presented results as means plus variables, and a qualitative review was performed on all 22 articles. Results: The meta-analysis showed no relationship between maternal TC, LDL-C, or HDL-C and increased risk of preterm birth, although, a near significant relationship between low maternal HDL-C concentration and preterm birth (p = .055). Importantly, associations increased when cholesterol concentrations were combined with inflammatory markers or metabolic syndrome factors. Conclusions: The relationship between maternal cholesterol levels and preterm birth is heterogeneous. Associations are strengthened when maternal cholesterol concentrations are combined with other factors that may be related to more recently defined lipoprotein functions.
机译：背景：以前患有早产的女性是心脏病的风险增加。由于自发的早产是影响全世界数百万儿童的不利妊娠结果，我们的目标是审查和分析在怀孕期间检查母体总胆固醇（TC），LDL-C和HDL-C浓度之间的关联的研究早产其潜在地限定生物标志物或靶向治疗。方法：进行搜索，发现了22篇文章，检查了母体血浆胆固醇浓度和早产的关联。在10篇文章中进行了META分析，将母体脂质浓度作为结果的那些进行，并呈现结果作为手段加变量，并且对所有22篇文章进行了定性审查。结果：Meta分析显示母体TC，LDL-C或HDL-C之间的关系，并增加了早产的风险，但是，低母体HDL-C浓度和早产之间的接近显着关系（P = .055） 。重要的是，当胆固醇浓度与炎症标记物或代谢综合征因子组合时，关联增加。结论：母体胆固醇水平与早产之间的关系是异质的。当母体胆固醇浓度与可能与更近最近定义的脂蛋白功能有关的其他因素时，加强联合。

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