...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Variants of HSD11B2 gene in hypertensive disorders of pregnancy
【24h】

Variants of HSD11B2 gene in hypertensive disorders of pregnancy

机译：HSD11B2基因在怀孕高血压障碍中的变体

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: One of the hypotheses concerning the etiology of gestational hypertension (GH) and pre-eclampsia (PE) assumes that they develop as a result of placenta malfunctioning at the early stage of pregnancy. Placental dysfunction is also associated with the decreased activity of 11-hydroxysteroid dehydrogenase 2 (11-HSD2), which in normal pregnancy protects the fetus from the excess of maternal cortisol.Objective: The aim of the study was to analyze the sequence of HSD11B2, a gene that encodes 11-HSD2, searching for mutations and haplotypes associated with the increased risk of GH or PE. Those may serve as potential genetic markers of GH and PE.Methods: The study was performed in case-control structure and included pregnant women (in third trimester) diagnosed with: GH, PE or being normotensive (control group). The research comprised DNA sequencing of HSD11B2, followed by restriction analysis (PCR-RFLP). The linkage disequilibrium analysis and haplotype-based case-control analysis were performed.Results: Six sequence variations were observed. Four mutations were indicated in the coding region of HSD11B2 and the other two in 3-UTR. Two SNPs: c.468C>A and c.534G>A were found to be in total disequilibrium.Conclusions: High variability in HSD11B2 sequence was indicated in the study population, but the relevance of observed SNPs to GH or PE development was not confirmed.
机译：介绍：关于妊娠期高血压（GH）和预普利普什西亚（PE）的病因的假设之一假设它们在怀孕早期出现的胎盘发生故障而发展。胎盘功能障碍也与11-羟基甾醇脱氢酶2（11-HSD2）的活性降低有关，其在正常妊娠中，保护胎儿免受过量的母体皮质醇。作用：研究的目的是分析HSD11B2的序列，编码11-HSD2的基因，搜索与增加GH或PE的风险增加相关的突变和单倍型。那些可以作为GH和PE的潜在遗传标记。方法：该研究是在病例对照结构中进行的，包括诊断为GH，PE或正常染色的孕妇（第三个三个月）。该研究包括HSD11B2的DNA测序，其次是限制性分析（PCR-RFLP）。进行连锁不平衡分析和基于单倍型病例对照分析。结果：观察到六个序列变化。在3-UTR中的HSD11B2的编码区和另外两个中指示四个突变。发现两种SNP：C.468C> A和C.534G> A和C.534G> A和C.534G> A总量不平衡。结论：研究人群中的HSD11B2序列的高变异性，但观察到的SNP与GH或PE开发的相关性未得到证实。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号