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首页> 外文期刊>The journal of knee surgery >Patellofemoral Cartilage Restoration: Indications, Techniques, and Outcomes of Autologous Chondrocytes Implantation, Matrix-Induced Chondrocyte Implantation, and Particulated Juvenile Allograft Cartilage
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Patellofemoral Cartilage Restoration: Indications, Techniques, and Outcomes of Autologous Chondrocytes Implantation, Matrix-Induced Chondrocyte Implantation, and Particulated Juvenile Allograft Cartilage

机译：Patellofemoral软骨恢复：自体软骨细胞植入，基质诱导的软骨细胞植入和颗粒状幼年异种移植软骨的适应症，技术和结果

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摘要

Focal chondral defects are common in the patellofemoral (PF) joint and can significantly impair the quality of life. The autologous chondrocytes implantation (ACI) technique has evolved over the past 20 years: the first-generation technique involves the use of a periosteal patch, the second-generation technique (collagen-cover) uses a type I/III collagen membrane, and the newest third-generation technique seeds and cultivates the collagen membrane with chondrocytes prior to implantation and is referred to as matrix-induced autologous chondrocyte implantation. Particulated juvenile allograft cartilage (PJAC) (DeNovo NT) is minced cartilage allograft from juvenile donors. A thorough physical exam is important, especially for issues affecting the PF joint, to isolate the location and source of pain, and to identify associated pathologies. Imaging studies allow further characterization of the lesions and identification of associated pathologies and alignment. Conservative management should be exhausted before proceeding with surgical treatment. Steps of surgical treatment are diagnostic arthroscopy and biopsy, chondrocytes culture and chondrocyte implantation for the three generations of ACI, and diagnostic arthroscopy and implantation for PJAC. The techniques and their outcomes will be discussed in this article.
机译：PatellofoMoral（PF）关节中的焦点缺陷很常见，可以显着损害生活质量。在过去的20年中，自体软骨细胞植入（ACI）技术已经进化：第一代技术涉及使用骨膜贴剂，第二代技术（胶原覆盖）使用I / III型胶原膜，以及在植入之前，最新的第三代技术种子并用软骨细胞培养胶原膜培养，并被称为基质诱导的自体软骨细胞植入。颗粒状幼年同种异体移植软骨（PJAC）（Denovo NT）是少年供体的碎软骨同种异体移植物。彻底的体检是重要的，特别是对于影响PF关节的问题，分离疼痛的位置和来源，并识别相关的病理学。成像研究允许进一步表征病变和相关病理和对准的鉴定。在进行外科治疗之前，保守管理应耗尽。手术治疗的步骤是诊断关节镜和活组织检查，软骨细胞培养和软骨细胞植入，用于三代ACI，以及PJAC的诊断关节镜检查和植入植入。本文将讨论技术及其结果。

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