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首页> 外文期刊>The Journal of neuropsychiatry and clinical neurosciences >Pavlov's Orienting Response in Frontotemporal Dementia
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Pavlov's Orienting Response in Frontotemporal Dementia

机译：Pavlov在前兆痴呆症的定向反应

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Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder with initial disturbances in socioemotional behavior in the absence of a sensitive diagnostic test. This study evaluated Pavlov's "orienting response" (OR) or "what is it?" reflex as a measure of their ability to refocus attention on socioemotional stimuli and as a potentially distinguishing measure for bvFTD. Ten patients with bvFTD were compared with 18 normal controls (NC) on ORs (defined as initial heart rate [HR] deceleration) to different pictures based on social and emotional (valence) differences from the International Affective Picture Stimuli. HR was measured while participants viewed pleasant-nonsocial (e.g., food), unpleasant-nonsocial (e.g., garbage), pleasant-social (e.g., babies), and unpleasant-social (e.g., violence) pictures. Participants watched each picture for 6 seconds, and the study examined HR changes during the first 2-second OR interval. The results showed significant differences in valence (pleasant-unpleasant) and valence-group interactions, but no effects of nonsocial-social. Whereas the NCs showed the expected HR deceleration (OR) to unpleasant stimuli, the bvFTD patients showed increased HRs without an initial refocusing. Decreased HR slowing to stimuli among the bvFTD patients correlated with increased scores on an emotional blunting scale. These findings suggest that decreased socioemotional behavior in bvFTD may be associated with decreased appreciation of emotional aspects of stimuli as evidenced by decreased ORs to emotional stimuli, regardless of social content. These findings also suggest further investigation of the OR in bvFTD as an early diagnostic measure for this disorder.
机译：行为变体额颞胎痴呆症（BVFTD）是一种神经变性障碍，在没有敏感的诊断测试的情况下具有社会间谍行为的初始紊乱。本研究评估了Pavlov的“定向反应​​”（或）或“它是什么？”反射作为他们重新关注社会间谍刺激和BVFTD的可能区分措施的衡量标准。将10例BVFTD患者与18例正常对照（NC）进行比较（定义为基于来自国际情感刺激的社会和情感（价）差异的不同图片的不同图片。在参与者观看令人愉快的非社会（例如，食物），不愉快的非社会（例如，垃圾），令人愉快的社会（例如，婴儿），以及令人愉快的社会（例如，暴力）图片的情况下进行测量。参与者观看每张照片6秒，研究在前2秒或间隔期间检查了HR变化。结果表明，价值（令人愉快 - 令人难以愉快）和价群相互作用差异显着差异，但没有非法社会的影响。然而，NCS显示出预期的HR减速度（或）令不愉快的刺激，BVFTD患者表现出HRS的增加而无需初始重新焦点。 BVFTD患者之间的刺激减缓了与情感截然尺度上的分数增加的刺激减缓。这些研究结果表明，不管社会内容，减少刺激的情绪方面的欣赏，人们对情感方面的升值减少可能与情感刺激的减少，无论社交内容如何减少。这些调查结果还表明进一步调查了BVFTD作为这种疾病的早期诊断措施。

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