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首页> 外文期刊>The annals of pharmacotherapy >Impact of a Combination Antibiotic Bag on Compliance With Surviving Sepsis Campaign Goals in Emergency Department Patients With Severe Sepsis and Septic Shock
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Impact of a Combination Antibiotic Bag on Compliance With Surviving Sepsis Campaign Goals in Emergency Department Patients With Severe Sepsis and Septic Shock

机译：组合抗生素袋对急诊科患者患者严重脓毒症和脓毒症休克患者的血糖竞选目标的影响

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Background: Severe sepsis and septic shock represent common presentations in the emergency department (ED) and have high rates of mortality. Guideline-recommended goals of care have been shown to benefit these patients, but can be difficult to provide. Objective: To determine whether the use of a premixed bag consisting of 2 g cefepime and 1 g vancomycin in 1000 mL of normal saline increases the probability of patients receiving Surviving Sepsis Campaign (SSC) recommendations for the initiation of antimicrobials and fluid challenge. Methods: This was a 6-month retrospective analysis conducted to determine the impact of an intervention on time to antimicrobials and fluid administration in patients with severe sepsis and septic shock. Patients presenting to the ED who received a diagnosis of severe sepsis or septic shock and were administered 2 antibiotics were eligible for inclusion. The primary outcome assessed was compliance with SSC recommendations for antibiotic and fluid goals within 3 hours of ED arrival. Results: A total of 160 patients were included. In the intervention group, 63.8% of patients met the primary outcome compared with 22.5% in the historical group (odds ratio = 2.32; 95% CI = 1.67-3.23). Time to administration of antibiotics was less with the combination antibiotic bag (CAB: median (IQR) = 72 (48-115) minutes; non-CAB: median (IQR) = 135 (102-244) minutes; P 0.001). Conclusion: This intervention significantly increased the proportion of patients provided with SSC goals of care. Such interventions have not been reported previously and could be meaningful in the management of severe sepsis and septic shock.
机译：背景：严重的败血症和化粪池震动代表急诊部（ED）的常见演示，并具有高的死亡率。指南建议的护理目标已被证明可以使这些患者受益，但可能难以提供。目的：确定使用由2g头孢哌序和1000ml生理盐水中的2g头脑和1g万古霉素组成的预混合袋是否增加了接受患者患者的患者的患者，以获得抗微生物和液体挑战的启动。方法：这是一个6个月的回顾性分析，以确定干预时间对严重脓毒症和脓毒症休克患者抗微生物和流体给药的影响。患者呈现给ED接受严重脓毒症或脓毒症休克的诊断，并施用2种抗生素有资格纳入。评估的主要结果是符合SSC的抗生素和流体目标在ed到来3小时内的建议。结果：共有160名患者。在干预组中，63.8％的患者达到了历史群体中的22.5％的主要结果（赔率比= 2.32; 95％CI = 1.67-3.23）。组合抗生素袋（驾驶室：中位数（IQR）= 72分钟;非驾驶室：中位数（IQR）= 135（102-244）分钟; P 0. 0.001）。结论：这种干预显着增加了SSC护理目标的患者的比例。此前尚未报道此类干预措施，可在严重脓毒症和脓毒症休克的管理方面有意义。

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