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首页> 外文期刊>The Journal of Nutritional Biochemistry >A high-corn-oil diet strongly stimulates mammary carcinogenesis, while a high-extra-virgin-olive-oil diet has a weak effect, through changes in metabolism, immune system function and proliferation/apoptosis pathways
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A high-corn-oil diet strongly stimulates mammary carcinogenesis, while a high-extra-virgin-olive-oil diet has a weak effect, through changes in metabolism, immune system function and proliferation/apoptosis pathways

机译：一种高玉米油饮食强烈刺激乳腺癌，而高度处女 - 橄榄油饮食具有弱效应，通过代谢，免疫系统功能和增殖/凋亡途径的变化

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摘要

Breast cancer is the most common malignancy in women worldwide, and dietary lipids are important environmental factors influencing its etiology. We have investigated the effects, and the mechanisms associated, of high-fat diets on 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors. Animals were fed a low-fat, a high-corn-oil (HCO) or a high-extra-virgin-olive-oil (HOO) diet from weaning or after induction. The HCO diet had a clear stimulating effect on mammary carcinogenesis, especially when dietary intervention started after induction, whereas the tumors from HOO diet groups exhibited clinical and morphological characteristics similar to those from low-fat controls. Transcriptomic and further protein and immunohistochemical analyses of tumors also indicated different modulatory effects of high-fat diets affecting relevant biological functions: metabolism, immunosurveillance and proliferation/apoptosis pathways. Thus, the results suggested different metabolic adaptations with increased glycolysis by effect of HOO diet. Moreover, leukocyte tumor infiltration and inflammation mediators showed increased cytotoxic T cells and decreased TGF beta 1 expression by the HOO diet, while the HCO one increased arginase expression and IL-1 alpha plasma levels. Furthermore, the study of proteins controlling proliferation/apoptosis pathways (Sema3A, Stat5, Smad1, Casp3) suggested an increase in proliferation by the HCO diet and an increase of apoptosis by the diet rich in olive oil. In conclusion, the HCO diet clearly stimulated mammary carcinogenesis, especially in the promotion phase, and induced molecular changes suggesting increased tumor proliferation/apoptosis balance and a proinflammatory microenvironment. The HOD diet, despite being high fat, had a weaker effect on tumorigenesis probably related to metabolic adaptations, enhanced immunosurveillance and increased apoptosis. (C) 2018 The Authors. Published by Elsevier Inc.
机译：乳腺癌是全世界妇女最常见的恶性肿瘤，膳食脂质是影响其病因的重要环境因素。我们已经研究了7,12-二甲基苄（A）蒽乳腺肿瘤的高脂饮食相关的效果和相关的机制。从断奶或诱导后，将动物喂养低脂肪，高玉米油（HCO）或高额外的维生橄榄油（HOO）饮食。 HCO饮食对乳腺癌的刺激作用明显，特别是当诱导后的膳食干预时，HOO饮食群体的肿瘤表现出与低脂肪对照的临床和形态特征类似。转录组和其他蛋白质和免疫组织化学分析肿瘤也表明了影响相关生物学功能的高脂肪饮食的不同调节作用：代谢，免疫抑制和增殖/凋亡途径。因此，结果表明通过HOO饮食的影响增加了糖酵解的不同代谢适应。此外，白细胞肿瘤浸润和炎症介质显示出细胞毒性T细胞增加，并通过HOO饮食降低了TGFβ1表达，而HCO一种增加的氨基酶表达和IL-1α血浆水平。此外，蛋白质控制增殖/凋亡途径（Sema3a，Stat5，Smad1，Casp3）的研究表明HCO饮食的增殖增加以及富含橄榄油中的饮食的细胞凋亡的增加。总之，HCO饮食清楚地刺激了乳腺发生，特别是在促进阶段，诱导分子变化，提高肿瘤增殖/凋亡平衡和促炎微环境。 HOD饮食尽管脂肪高，但对肿瘤发生的影响较弱，肿瘤鉴定可能与代谢适应有关，增强免疫抑制和增加的细胞凋亡。 （c）2018作者。 elsevier公司发布

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  • 来源
    《The Journal of Nutritional Biochemistry》 |2019年第2019期|共10页
  • 作者

    Escrich Raquel; Costa Irmgard; Moreno Montserrat; Cubedo Marta; Vela Elena; Escrich Eduard; Moral Raquel;

  • 作者单位

    Univ Autonoma Barcelona Fac Med Dept Cell Biol Physiol &

    Immunol Physiol Unit Avinguda Can Domenech E-08193 Barcelona Cerdanyola Del Spain;

    Corp Parc Tauli UDIAT Dept Pathol Barcelona 08208 Spain;

    Univ Autonoma Barcelona Fac Med Dept Cell Biol Physiol &

    Immunol Physiol Unit Avinguda Can Domenech E-08193 Barcelona Cerdanyola Del Spain;

    Univ Barcelona Dept Stat E-08028 Barcelona Spain;

    Univ Autonoma Barcelona Fac Med Dept Cell Biol Physiol &

    Immunol Physiol Unit Avinguda Can Domenech E-08193 Barcelona Cerdanyola Del Spain;

    Univ Autonoma Barcelona Fac Med Dept Cell Biol Physiol &

    Immunol Physiol Unit Avinguda Can Domenech E-08193 Barcelona Cerdanyola Del Spain;

    Univ Autonoma Barcelona Fac Med Dept Cell Biol Physiol &

    Immunol Physiol Unit Avinguda Can Domenech E-08193 Barcelona Cerdanyola Del Spain;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    Dietary lipids; Breast cancer; Olive oil; Transcriptome; Immune system; Apoptosis; Metabolism;

    机译：膳食脂质;乳腺癌;橄榄油;转录组;免疫系统;细胞凋亡;新陈代谢;

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