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首页> 外文期刊>The Journal of Nutritional Biochemistry >Omega-3 decreases D1 and D2 receptors expression in the prefrontal cortex and prevents amphetamine-induced conditioned place preference in rats
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Omega-3 decreases D1 and D2 receptors expression in the prefrontal cortex and prevents amphetamine-induced conditioned place preference in rats

机译：Omega-3降低了前额叶皮质中的D1和D2受体表达，并防止了大鼠的含量诱导的条件偏好

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摘要

Amphetamine (AMPH) abuse is a serious public health problem due to the high addictive potential of this drug, whose use is related to severe brain neurotoxicity and memory impairments. So far, therapies for psychostimulant addiction have had limited efficacy. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have shown beneficial influences on the prevention and treatment of several diseases that affect the central nervous system. Here, we assessed the influence of fish oil (FO), which is rich in n-3 PUFA, on withdrawal and relapse symptoms following re-exposure to AMPH. Male Wistar rats received d,l-AMPH or vehicle in the conditioned place preference (CPP) paradigm for 14 days. Then, half of each experimental group was treated with FO (3 g/kg, p.o.) for 14 days. Subsequently, animals were re-exposed to AMPH-CPP for three additional days, in order to assess relapse behavior. Our findings have evidenced that FO prevented relapse induced by AMPH reconditioning. While FO prevented AMPH-induced oxidative damages in the prefrontal cortex, molecular assays allowed us to observe that it was also able to modulate dopaminergic cascade markers (DAT, TH, VMAT-2, D1R and D2R) in the same brain area, thus preventing AMPH-induced molecular changes. To the most of our knowledge, this is the first study to show a natural alternative tool which is able to prevent psychostimulant relapse following drug withdrawal. This non-invasive and healthy nutraceutical may be considered as an adjuvant treatment in detoxification clinics. (C) 2019 Elsevier Inc. All rights reserved.
机译：Amphetamine（AMPH）滥用是由于该药物的高上瘾潜力，其使用与严重的脑神经毒性和记忆障碍有关。到目前为止，精神疗法成瘾的疗法有限。 Omega-3多不饱和脂肪酸（N-3 PUFA）对预防和治疗几种影响中枢神经系统的疾病显示有益的影响。在这里，我们评估了鱼油（Fo）的影响，该影响在N-3 Pufa富含N-3 PUFA，在重新接触到AMPH后的戒断和复发症状。雄性Wistar大鼠在条件的地方偏好（CPP）范式14天内收到D，L-AMPH或载体。然后，将一半的实验组用FO（3g / kg，p.o.）处理14天。随后，将动物重新暴露于AMPH-CPP三次，以评估复发行为。我们的研究结果证明，由于AMPH再修复，防止了复发。虽然Fo防止在前额叶皮质中的AMPH诱导的氧化损伤，但是分子测定允许我们观察到它还能够在同一脑区域中调节多巴胺能级联标记（DAT，VMAT-2，D1R和D2R），从而防止AMPH诱导的分子变化。为了大多数人的知识，这是第一项展示一种展示一种自然替代工具的研究，该工具能够在药物戒断后防止精神兴奋剂复发。这种非侵入性和健康的营养保健品可以被认为是排毒诊所中的佐剂治疗。 （c）2019 Elsevier Inc.保留所有权利。

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