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首页> 外文期刊>The Journal of Nutritional Biochemistry >Secretion of a gastrointestinal hormone, cholecystokinin, by hop-derived bitter components activates sympathetic nerves in brown adipose tissue
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Secretion of a gastrointestinal hormone, cholecystokinin, by hop-derived bitter components activates sympathetic nerves in brown adipose tissue

机译：分泌胃肠激素，Cholecystokinin，通过霍衍生的苦组分激活棕色脂肪组织中的交感神经

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Matured hop bitter acids (MHBA) are oxidation products from bitter components in hops, which are used widely as food materials to add flavor and bitterness in beer production. Our previous study has shown that MHBA induces thermogenesis in brown adipose tissue (BAT) via sympathetic nerves in rodents and reduces body fat in healthy adults. However, it is unclear how MHBA affects the sympathetic nervous system. In this study, we demonstrate that MHBA treatment of enteroendocrine cells increases Ca2+ levels and induces the secretion of the gastrointestinal hormone, cholecystokinin (CCK), in a dose-dependent manner. These effects were eliminated by Ca2+ depletion from the medium or blockers of L-type voltage-sensitive Ca2+ channels during pretreatment. Induction of CCK secretion by MHBA was also confirmed using isolated rat small intestines. Elevation of the sympathetic nerve activity innervating BAT (BAT-SNA) and BAT temperature by MHBA administration in rats was blocked by pretreatment with a CCK receptor 1 (CCK1R) antagonist. Moreover, the intraperitoneal injection of CCK fragment elevated BAT-SNA, and this increase was blocked by subdiaphragmatic vagotomy. These results demonstrate that MHBA induces CCK secretion in the gastrointestinal tracts and elevates BAT-SNA via CCK1R and vagal afferent nerves. In addition, MHBA increases BAT temperature via CCK1R. Our findings reveal a novel mechanism of the beneficial metabolic effects of food ingredients. (C) 2018 The Authors. Published by Elsevier Inc.
机译：成熟的啤酒花苦酸（MHBA）是来自啤酒花中苦组分的氧化产物，其被广泛用作食品材料，以增加啤酒生产中的风味和苦味。我们以前的研究表明，MHBA通过啮齿动物中的交感神经中的棕色脂肪组织（BAT）在棕色脂肪组织（BAT）中的热生成，并减少健康成年人的身体脂肪。但是，目前尚不清楚MHBA如何影响交感神经系统。在这项研究中，我们证明了进肠内分泌细胞的MHBA治疗增加了Ca2 +水平，并以剂量​​依赖性方式诱导胃肠激素，胆囊素（CCK）的分泌。在预处理期间，通过从L型电压敏感CA2 +通道的培养基或阻塞者消除这些效果。使用分离的大鼠小肠也证实了MHBA的CCK分泌的诱导。通过用CCK受体1（CCK1R）拮抗剂预处理阻断了MHBA施用的同情神经活性的升高（BAT-SNA）和蝙蝠温度通过预处理阻断。此外，CCK片段的腹膜内注射率升高的蝙蝠Sna，并且通过子噬菌型侵扰术阻断这种增加。这些结果表明，MHBA在胃肠道中诱导CCK分泌物，并通过CCK1R和缩小传入神经升高BAT-SNA。此外，MHBA通过CCK1R增加蝙蝠温度。我们的研究结果揭示了食品成分有益代谢效果的新机制。 （c）2018作者。 elsevier公司发布

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