• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Nutritional Biochemistry >Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis
【24h】

Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis

机译：双歧杆菌具有5-羟基转抗的作用，减轻了抑郁症和相关微生物症失育症的症状

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Depression disorder is rapidly advancing worldwide, and therapeutic strategy through gut-brain axis has been proven to be effective in the treatment. Here we studied the effect of lactic acid bacteria (LAB) treatment on depression. C57BL/6J mice were administered with LAB during a 5-week chronic unpredictable mild stress. Bifidobacterium longum subsp. infantis E41 and Bifidobacterium breve M2CF22M7, which improved the expression of Tphl and secretion of 5-hydroxytryptophan (5-HTP) in RIN14B cells, significantly reduced depressive behaviors of mice in the forced swim test, sucrose preference test and step-down test, as well as increased the level of 5-hydroxytryptamine and brain-derived neurotrophic factor concentration in brain. Besides, M2CF22M7 reduced the serum corticosterone level. E41 increased cecal butyrate level, which significantly and positively correlated with some depression-related indexes. Using 16S rRNA-amplicon sequencing of faces, E41 and M2CF22M7 were found to improve the chronic-stress-induced microbial dysbiosis. They also normalized the host's pathways involving metabolism and gene information processing. These results indicate that Bifidobacterium E41 and M2CF22M7 have an antidepressant effect in mice partly in a 5-HTP dependent and microbiota-regulating manner. Nurturing the gut microbiota with these strains may become an emerging therapeutic way for mood disorder. (C) 2019 Elsevier Inc. All rights reserved.
机译：抑郁症正在全球迅速推进，通过肠脑轴的治疗策略已被证明在治疗中有效。在这里，我们研究了乳酸菌（实验室）治疗对抑郁症的影响。在5周慢性不可预测的温和胁迫下，用实验室给予C57BL / 6J小鼠。双歧杆菌Longum subsp。 Infantiis E41和Bifidobacterium Breve M2M2M7，改善了TPH1和5-羟基对细胞（5-HTP）的分泌物在rin14b细胞中的表达，在强制游泳测试中显着降低了小鼠的抑郁行为，蔗糖偏好测试和降压测试，如随着脑中的5-羟基 - 羟基胺和脑衍生的神经营养因子浓度的水平增加。此外，M2CF22M7还减少了血清皮质酮水平。 E41增加了肠丁酸丁酸酯水平，与一些抑郁症相关指标显着和正相关。使用16S rRNA - 扩增子测序面，E41和M2CF22M7被发现改善慢性应激诱导的微生物消带症。他们还标准化了涉及代谢和基因信息处理的宿主的途径。这些结果表明，Bifidobacterium E41和M2CF22M7在小鼠中具有抗抑郁作用部分，部分地以5-HTP依赖性和微生物群调节方式。用这些菌株培养肠道微生物群可能成为情绪障碍的新兴治疗方法。 （c）2019 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号