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首页> 外文期刊>The Journal of Nutritional Biochemistry >Maternal short and medium chain fatty acids supply during early pregnancy improves embryo survival through enhancing progesterone synthesis in rats
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Maternal short and medium chain fatty acids supply during early pregnancy improves embryo survival through enhancing progesterone synthesis in rats

机译：早孕期间的孕产妇短和中链脂肪酸供应通过提高大鼠孕酮合成来改善胚胎生存

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摘要

Exploring strategies to prevent miscarriage in women or early pregnancy loss in mammals is of great importance. Manipulating maternal lipid metabolism to maintain sufficient progesterone level is an effective way. To investigated the embryo loss and progesterone synthesis impacts of short and medium chain fatty acids on the lipid metabolism, pregnancy outcome and embryo implantation were investigated in rats fed the pregnancy diets supplemented without or with 0.1% sodium butyrate (SB), 0.1% sodium hexanoate (SH), or 0.1% sodium caprylate (SC) during the entire pregnancy and early pregnancy, respectively, followed with evaluation of potential mechanisms. Maternal SB, SH, or SC supply significantly improved live litter size and embryo implantation in rats. Serum progesterone, arachidonic acid, and phospholipid metabolites levels were significantly increased in response to maternal SB, SH, and SC supply. The expression of key genes involved in ovarian steroidogenesis and granulosa cell luteinization were elevated in ovaries and primary cultured granulosa cells, including cluster of differentiation 36 (CD36), steroidogenic acute regulatory protein (StAR), and cholesterol side-chain cleavage enzyme (CYP11A1). Additionally, the expression of lysophosphatidic acid receptor 3 (LPA(3)) and cyclooxygenase-2 (COX2) related with phospholipid metabolism were enhanced in uterus in vivo and in in vitro cultured uterine tissue. In conclusion, maternal SB, SH and SC supply reduced early pregnancy loss through modulating maternal phospholipid metabolism and ovarian progesterone synthesis in rats. Our results have important implications that short or medium chain fatty acids have the potential to prevent miscarriage in women or early pregnancy loss in mammals. (C) 2019 The Authors. Published by Elsevier Inc.
机译：探索防止女性流产或哺乳动物早期妊娠的策略具有重要意义。操纵母体脂质代谢以维持足够的孕酮水平是一种有效的方法。为了研究胚胎损失和孕酮的脂肪酸对脂质代谢对脂质代谢的影响，在喂食妊娠饮食的大鼠中研究了妊娠结局和胚胎植入，没有或含0.1％丁酸钠（Sb），0.1％己酸钠（SH），或0.1％毛酸钠（SC）分别在整个妊娠和早孕期间，随后评估潜在机制。母体SB，SH或SC供应显着提高了大鼠的活窝块和胚胎植入。患有母体SB，SH和SC供应的血清孕酮，花生素酸和磷脂代谢物水平显着增加。参与卵巢穗间诱导和颗粒细胞鳞粉化的关键基因的表达在卵巢和初级培养的颗粒细胞中升高，包括分化簇36（CD36），类固醇型急性调节蛋白（星）和胆固醇侧链切割酶（CYP11A1） 。另外，在体内和体外培养的子宫组织中，在子宫中增强了与磷脂代谢相关的溶血磷脂酸受体3（LPA（3））和环氧化酶-2（COX2）的表达。总之，母体SB，SH和SC供应通过调节大鼠母体磷脂代谢和卵巢孕酮合成来降低早期妊娠损失。我们的结果具有重要的含义，即短期或中链脂肪酸有可能预防妇女的流产或哺乳动物早期妊娠。 （c）2019年作者。 elsevier公司发布

著录项

  • 来源
    《The Journal of Nutritional Biochemistry》 |2019年第2019期|共10页
  • 作者

    Ye Qianhong; Cai Shuang; Wang Shuai; Zeng Xiangzhou; Ye Changchuan; Chen Meixia; Zeng Xiangfang; Qiao Shiyan;

  • 作者单位

    China Agr Univ Minist Agr Feed Ind Ctr State Key Lab Anim Nutr Beijing 100193 Peoples R China;

    China Agr Univ Minist Agr Feed Ind Ctr State Key Lab Anim Nutr Beijing 100193 Peoples R China;

    Huazhong Agr Univ Dept Anim Nutr &

    Feed Sci Coll Anim Sci &

    Technol Wuhan 430070 Hubei Peoples R China;

    China Agr Univ Minist Agr Feed Ind Ctr State Key Lab Anim Nutr Beijing 100193 Peoples R China;

    China Agr Univ Minist Agr Feed Ind Ctr State Key Lab Anim Nutr Beijing 100193 Peoples R China;

    China Agr Univ Minist Agr Feed Ind Ctr State Key Lab Anim Nutr Beijing 100193 Peoples R China;

    China Agr Univ Minist Agr Feed Ind Ctr State Key Lab Anim Nutr Beijing 100193 Peoples R China;

    China Agr Univ Minist Agr Feed Ind Ctr State Key Lab Anim Nutr Beijing 100193 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    Early embryo loss; Fatty acids; Lipid metabolomics; Phospholipids; Progesterone;

    机译：早期胚胎损失;脂肪酸;脂质代谢物;磷脂;孕酮;

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