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首页> 外文期刊>The Journal of Nutritional Biochemistry >Conjugated linoleic acid and nitrite attenuate mitochondrial dysfunction during myocardial ischemia
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Conjugated linoleic acid and nitrite attenuate mitochondrial dysfunction during myocardial ischemia

机译：缀合的亚油酸和亚硝酸盐在心肌缺血期间衰减线粒体功能障碍

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Cardiovascular health is influenced by dietary composition and the western diet is composed of varying types/amounts of fat. Conjugated linoleic acid (cLA) is an abundant dietary unsaturated fatty acid associated with health benefits but its biological signaling is not well understood. Nitrite is enriched in vegetables within the diet and can impact signaling of unsaturated fatty acids; however, its role on cLA signaling is not well understood. Elucidating how nitrite may impact the biological signaling of cLA is important due to the dietary consumption of both cLA and nitrite in the western diet. Since co-administration of cLA and nitrite results in cardioprotection during myocardial infarction (MI), it was hypothesized that cLA and nitrite may affect cardiac mitochondria! respiratory function and complex activity in MI. C57BL/6J mice were treated with cLA and nitrite for either 10 or 13 days, where MI was induced on day 3. Following treatment, respiration and complex activity were measured. Among the major findings of this study, cLA treatment (10 days) decreases state 3 respiration in vivo. Following MI, nitrite alone and in combination with cLA attenuates increased state 3 respiration and decreases hydrogen peroxide levels. Further, nitrite and cLA co-treatment attenuates increased complex III activity after MI. These results suggest that cLA, nitrite and the combination significantly alter cardiac mitochondrial respiratory and electron transport chain activity in vivo and following MI. Overall, the daily consumption of cLA and nitrite in the diet can have diverse cardiovascular implications, some of which occur at the mitochondrial level. (C) 2016 Elsevier Inc. All rights reserved.
机译：心血管健康受膳食成分的影响，西方饮食由不同类型/脂肪的种类组成。缀合的亚油酸（CLA）是一种与健康益处相关的丰富的膳食不饱和脂肪酸，但其生物信号传导不太了解。亚硝酸盐在饮食中富含蔬菜，可以影响不饱和脂肪酸的信号;然而，它对CLA信号传导的作用并不充分了解。阐明亚硝酸盐可能会影响CLA的生物信号，这是由于西方饮食中CLA和亚硝酸盐的饮食消耗。由于在心肌梗死期间CLA和亚硝酸盐的共同施用，因此假设CLA和亚硝酸盐可能会影响心肌细胞粒细胞！ MI中呼吸功能与复杂活性。将C57BL / 6J小鼠用CLA和亚硝酸盐处理10或13天，其中在第3天诱导MI。测量后，测量呼吸和复合活性。本研究的主要发现中，CLA治疗（10天）降低了体内呼吸的态度。在MI，单独亚硝酸盐和CLA组合衰减增加的状态3呼吸并降低过氧化氢水平。此外，亚硝酸盐和CLA共处理衰减MI后的复杂III活性增加。这些结果表明，CLA，亚硝酸盐和该组合显着改变体内心脏线粒体呼吸和电子传输链活性和后续MI。总体而言，饮食中CLA和亚硝酸盐的日常消费可以具有多样化的心血管影响，其中一些在线粒体层面发生。 （c）2016年Elsevier Inc.保留所有权利。

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