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首页> 外文期刊>The Journal of Nutritional Biochemistry >Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice
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Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice

机译：膳食干李增骨质量增加，抑制促炎细胞因子并促进雄性小鼠峰值骨质肿块

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Nutrition is an important determinant of bone health and attainment of peak bone mass. Diets containing dried plum (DP) have been shown to increase bone volume and strength. These effects may be linked to the immune system and DP-specific polyphenols. To better understand these relationships, we studied DP in skeletally mature (6-month -old) and growing (1- and 2-month-old) C57BI/6 male mice. In adult mice, DP rapidly (2 weeks) increased bone volume (+32%) and trabecular thickness (+24%). These changes were associated with decreased osteoclast surface (Oc.S/BS) and decreased serum CTX, a marker of bone resorption. The reduction in Oc.S/BS was associated with a reduction in the osteoclast precursor pool. Osteoblast surface (Ob.S/BS) and bone formation rate were also decreased suggesting that the gain in bone in adult mice is a consequence of diminished bone resorption and formation, but resorption is reduced more than formation. The effects of DP on bone were accompanied by a decline in interleukins, TNF and MCP-1, suggesting that DP is acting in part through the immune system to suppress inflammatory activity and reduce the size of the osteoclast precursor pool. Feeding DP was accompanied by an increase in plasma phenolics, some of which have been shown to stimulate bone accrual. In growing and young adult mice DP at levels as low as 5% of diet (w/w) increased bone volume. At higher levels (DP 25%), bone volume was increased by as much as 94%. These data demonstrate that DP feeding dramatically increases peak bone mass during growth. (C) 2016 Elsevier Inc. All rights reserved.
机译：营养是骨骼健康和峰值骨质肿块的重要决定因素。已显示含有干李（DP）的饮食以增加骨体积和强度。这些效果可以与免疫系统和特异性多酚联系起来。为了更好地了解这些关系，我们研究了骨骼成熟（6个月 - old）和生长（1-2个月大）C57Bi / 6只雄性小鼠的DP。在成年小鼠中，DP快速（＆lt 2周）增加骨体积（+ 32％）和毛线厚度（+ 24％）。这些变化与破骨细胞表面（OC 3 Bs）降低有关，并降低血清CTX，骨吸收的标志物。 OC 3 Bs的还原与破骨细胞前体池的还原有关。成骨细胞表面（OB.S / BS）和骨形成率也降低表明成年小鼠中的骨中的增益是骨吸收和形成减少的结果，但吸收比形成更低。 DP对骨骼对骨的影响伴随着白细胞介素，TNF和MCP-1的下降，表明DP通过免疫系统部分作用以抑制炎症活性并减少破骨细胞前体池的大小。饲料DP伴随着血浆酚类的增加，其中一些已被证明刺激骨骼应计。在生长和年轻的成年小鼠DP中，水平低至5％的饮食（w / w）增加骨体积。在较高水平（DP 25％）中，骨体积增加高达94％。这些数据表明DP饲养在生长期间显着增加了峰值骨质量。 （c）2016年Elsevier Inc.保留所有权利。

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