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首页> 外文期刊>The Journal of Nutritional Biochemistry >Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice
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Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice

机译：饮食柚皮素补充通过调节小鼠的自身免疫性炎症反应来衰减实验性自身免疫性脑炎

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摘要

Autoimmune disease is highly prevalent in humans. Since conventional therapies have limited efficacy and often come with significant side effects, nutrition may provide an alternative and complementary approach to improving autoimmune disorders. Naringenin, a flavonoid found in citrus fruits, has been shown to have anti-inflammatory and antioxidant properties. Using the experimental autoimmune encephalomyelitis (EAE), a rodent model of human multiple sclerosis, we determined the effect of dietary naringenin (0.5%) on autoimmune disease. We found that naringenin reduced the incidence, delayed the onset, and attenuated the symptoms of EAE, which were accompanied by reduced immune cell infiltration and demyelination in the spinal cord. Additionally, the pro inflammatory CD4(+) T cell subsets Th1, Th9, and Th17 cells together with their respective transcription factors T-bet, PU.1, and ROR gamma t were reduced in both the central nervous system (CNS) and lymph nodes of EAE mice fed naringenin while no difference was found in Th2 and regulatory T cell (Treg) populations in either CNS or lymph nodes between the two groups. We further showed that pathologic T cell proliferation induced by ex vivo re-stimulation with MOG(35-55) and proinflammatory cytokines IL-6 and TNF-alpha were lower in naringenin-fed mice than in the control mice. Additionally, we found that naringenin treatment inhibited mRNA expression of CXCL10 (Th1 recruiting chemokine), vascular cell adhesion molecule-1 (VCAM-1), and VLA-4 (VCAM-1 ligand) in the CNS of EAE mice. Altogether, these results indicate that naringenin may have a potential to ameliorate autoimmune disease by favorably modulating autoimmune response. (C) 2017 Elsevier Inc. All rights reserved.
机译：自身免疫性疾病在人类中普遍存在。由于常规疗法有限，并且通常具有显着的副作用，因此营养可以提供改善自身免疫障碍的替代和互补方法。 Naringenin，一种在柑橘类水果中发现的黄酮类化合物，已被证明具有抗炎和抗氧化性能。使用实验性自身免疫性脑脊髓炎（EAE），人类多发性硬化的啮齿动物模型，我们确定了膳食柚皮素（0.5％）对自身免疫疾病的影响。我们发现柚皮素减少了发病率，延迟发病，并减弱了EAE的症状，伴随着脊髓中的免疫细胞浸润和脱髓鞘伴随。另外，在中枢神经系统（CNS）和淋巴中，Pro炎症CD4（+）T细胞亚群Th1，Th9和Th17细胞与它们各自的转录因子T-Bet，PU.1和RORγTγT. EAE小鼠的节点喂养Naringenin，而在两组之间的CNS或淋巴结中的TH2和调节T细胞（Treg）群中没有发现差异。进一步表明，在Naringenin-Fred小鼠中，通过MOG（35-55）和促炎细胞因子IL-6和TNF-α诱导的病理T细胞增殖比在对照小鼠中较低。另外，我们发现鼻腔治疗抑制了EAE小鼠CNS中CXCL10（Th1募集趋化因子），血管细胞粘附分子-1（VCAM-1）和VLA-4（VCAM-1配体）的mRNA表达。总的来说，这些结果表明，纳林蛋白可能通过有利地调节自身免疫反应来改善自身免疫疾病。 （c）2017年Elsevier Inc.保留所有权利。

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