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首页> 外文期刊>The Journal of Nutritional Biochemistry >A Western-type dietary pattern and atorvastatin induce epicardial adipose tissue interferon signaling in the Ossabaw pig
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A Western-type dietary pattern and atorvastatin induce epicardial adipose tissue interferon signaling in the Ossabaw pig

机译：西方型膳食图案和阿托伐他汀诱导奥塞拉方猪中的心外膜脂肪组织干扰素信号

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Epicardial adipose tissue (EAT) inflammation is thought to potentiate the development of coronary artery disease (CAD). Overall diet quality and statin therapy are important modulators of inflammation and CAD progression. Our objective was to examine the effects and interaction of dietary patterns and statin therapy on EAT gene expression in the Ossabaw pig. Pigs were randomized to 1 of 4 groups; Heart Healthy diet (high in unsaturated fat, unrefined grain, fruits/ vegetables [HHD]) or Western diet (high in saturated fat, cholesterol, refined grain [WD]), with or without atorvastatin. Diets were fed in isocaloric amounts for 6 months. A two-factor edge R analysis identified the differential expression of 21 genes. Relative to the HHD, the WD resulted in a significant 12-fold increase of radical s-adenosyl methionine domain containing 2 (RSAD2), a gene induced by interferon signaling. Atorvastatin led to the significant differential expression of 17 genes predominately involved in interferon signaling. Results were similar using the Porcine Translational Research Database. Pathway analysis confirmed the up-regulation of interferon signaling in response to the WD and atorvastatin independently. An expression signature of the largely interferon related differentially expressed genes had no predictive capability on a histological assessment of atherosclerosis in the underlying coronary artery. These results suggest that a WD and atorvastatin evoke an interferon mediated immune response in EAT of the Ossabaw pig, which is not associated with the presence of atherosclerosis. (C) 2019 Elsevier Inc. All rights reserved.
机译：心外膜脂肪组织（吃）炎症被认为具有冠状动脉疾病（CAD）的发育。整体饮食质量和他汀类药物治疗是炎症和CAD进展的重要调节剂。我们的目标是探讨膳食模式和他汀类药物治疗在Ossabaw猪中吃基因表达的影响和相互作用。猪随机分为4组中的1个;心健康饮食（不饱和脂肪，未精制的谷物，水果/蔬菜[HHD]）或西方饮食（高饱和脂肪，胆固醇，精制谷物[WD]），有或没有阿托伐他汀。饮食以异蜂制量喂养6个月。双因素边缘R分析鉴定了21个基因的差异表达。相对于HHD，WD导致含有2（RSAD2）的基团S-腺苷甲硫氨酸结构域的显着12倍，是由干扰素信号传导诱导的基因。阿托伐他汀导致了主要涉及干扰素信号传导的17个基因的显着差异表达。使用猪翻译研究数据库类似的结果。途径分析证实了干扰素信号响应于WD和阿托伐他汀的抑制。基于干扰素相关的差异表达基因的表达签名对底层冠状动脉中动脉粥样硬化的组织学评估没有预测性能力。这些结果表明，WD和阿托伐他汀在吃奥塞拉方猪的食用中引诱干扰素介导的免疫反应，这与动脉粥样硬化的存在无关。 （c）2019 Elsevier Inc.保留所有权利。

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