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A critical review on anti-angiogenic property of phytochemicals

机译：植物化学抗血管生成特性的批判性研究

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摘要

Angiogenesis, a process involved in neovascularization, has been found to be associated with several metabolic diseases like cancer, retinopathy etc. Thus, currently, the focus on anti-angiogenic therapy for treatment and prevention of diseases has gained significant attention. Currently available Food and Drug Administration (FDA) approved drugs are targeting either vascular endothelial growth factor or it's receptor, but in the long term, these approaches were shown to cause several side effects and the chances of developing resistance to these drugs is also high. Therefore, identification of safe and cost-effective anti-angiogenic molecules is highly imperative. Over the past decades, dietary based natural compounds have been studied for their anti-angiogenic potential which provided avenues in improving the angiogenesis based therapy. In this review, major emphasis is given to the molecular mechanism behind anti-angiogenic effect of natural compounds from dietary sources. (C) 2019 Elsevier Inc. All rights reserved.
机译：已发现血管生成，血管内涉及新血管化的过程与癌症，视网膜病变等多种代谢疾病有关。因此，目前，对抗血管生成治疗治疗和预防疾病的关注产生了显着的关注。目前可用的食品和药物管理局（FDA）批准的药物靶向血管内皮生长因子或其受体，但从长期后，这些方法显示出几种副作用，并且对这些药物的抗性的可能性也很高。因此，鉴定安全且经济高效的抗血管生成分子是高度势不平的。在过去的几十年中，已经研究了膳食基础的天然化合物，用于其抗血管生成潜力，该潜力为改善基于血管生成的血管生成的抗血管生成潜力提供了途径。在本综述中，重大重点是饮食来源的天然化合物的抗血管生成效果背后的分子机制。 （c）2019 Elsevier Inc.保留所有权利。

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