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首页> 外文期刊>The journal of obstetrics and gynaecology research >Review: Chronic endometritis and its effect on reproduction
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Review: Chronic endometritis and its effect on reproduction

机译：回顾：慢性子宫内膜炎及其对繁殖的影响

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摘要

Abstract Aim Chronic endometritis (CE) is a disease of continuous and subtle inflammation characterized by the infiltration of plasma cells in the endometrial stromal area. Although the clinical significance of CE has been thought in clinical practice for a long time because it is either asymptomatic or presents with subtle symptoms, recent studies have shown the potential adverse effects of CE on fertility. In the present review, we focus on the concept, diagnosis, etiology, pathophysiology, diagnosis, impact on reproduction and treatment for it to understand CE. Methods The published articles were reviewed. Results The prevalence of CE has been found to be 2.8–56.8% in infertile women, 14–67.5% in women with recurrent implantation failure (RIF), and 9.3–67.6% in women with recurrent pregnancy loss. Microorganisms are thought to be a main cause of CE, since antibiotic treatment has been reported to be an effective therapy for CE. Common bacteria are frequently detected in the uterine cavity of CE patients by microbial culture. In CE endometrium, the prevalence of immune cells and decidualization has been reported to be modified, and these modifications are thought to adversely affect fertility. The gold standard for the diagnosis of CE is the histological detection of plasma cells in the stromal area of the endometrium in endometrial specimens, although universally accepted criteria for the diagnosis of CE have not been determined. The treatment currently thought to be most effective for the recovery of fertility in CE is administration of oral antibiotics. Patients whose CE has been cured have been reported to have a higher ongoing pregnancy rate, clinical pregnancy rate, and implantation rate compared with patients with persistent CE. Conclusion CE greatly affects implantation and impairs fertility. Antibiotic administration is an effective therapeutic option. Pregnancy rate in in vitro fertilization is improved when CE is cured by antibiotic.
机译：摘要目的慢性子宫内膜炎（CE）是一种连续和细微炎症的疾病，其特征在于子宫内膜间构区域中的血浆细胞渗透。虽然CE的临床意义一直在临床实践中长期以来被认为是因为它是无症状或具有微妙症状的症状，但最近的研究表明CE对生育的潜在不利影响。在本综述中，我们专注于概念，诊断，病因，病理生理学，诊断，对其进行繁体和治疗的影响，以了解CE。方法审查已发表的文章。结果患有妊娠期植入失败（RIF）的妇女患有14-67.5％的孕妇的患病率为2.8-56.8％，患有妊娠损失的妇女的患者，14-67.5％。微生物被认为是Ce的主要原因，因为据报道，抗生素治疗是CE的有效治疗。通过微生物培养在CE患者的子宫腔内经常检测常见细菌。在CE子宫内膜中，据报告了免疫细胞和脱扣化的患病率被修改，并且这些修改被认为对生育能力产生不利影响。诊断Ce的金标是子宫内膜中子宫内膜中子宫内膜的基质区域中血浆细胞的组织学检测，尽管尚未确定诊断的诊断标准。目前认为最有效地在Ce中恢复生育能力是最有效的。施用口服抗生素。据报道，CE已治愈的患者具有较高的妊娠率，临床妊娠率和植入率与持久性CE的患者相比具有更高的妊娠率，临床妊娠率和植入率。结论CE极大地影响植入和损害生育能力。抗生素给药是一种有效的治疗选择。当CE通过抗生素治愈时，体外施肥的妊娠率得到改善。

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  • 作者

    Kimura Fuminori; Takebayashi Akie; Ishida Mitsuaki; Nakamura Akiko; Kitazawa Jun; Morimune Aina; Hirata Kimiko; Takahashi Akimasa; Tsuji Shoko; Takashima Akiko; Amano Tsukuru; Tsuji Shunichiro; Ono Tetsuo; Kaku Shoji; Kasahara Kyoko; Moritani Suzuko; Kushima Ryoji; Murakami Takashi;

  • 作者单位

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Pathology and Laboratory MedicineKansai Medical UniversityOsaka Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

    Department of Clinical Laboratory MedicineShiga University of Medical ScienceOtsu Japan;

    Department of Clinical Laboratory MedicineShiga University of Medical ScienceOtsu Japan;

    Department of Obstetrics and GynecologyShiga University of Medical ScienceOtsu Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 妇产科学;
  • 关键词

    chronic endometritis; infertility; repeated implantation failure;

    机译：慢性子宫内膜炎;不孕症;重复植入失败;

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