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首页> 外文期刊>The journal of obstetrics and gynaecology research >Multiple primary cancers associated with endometrial and ovarian cancers: An analysis based upon the Japan Autopsy Annual Database from 2002 to 2010
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Multiple primary cancers associated with endometrial and ovarian cancers: An analysis based upon the Japan Autopsy Annual Database from 2002 to 2010

机译：与子宫内膜和卵巢癌相关的多次癌症：2002年至2010年日本尸检年度数据库的分析

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Abstract Aim A thorough analysis of multiple primary cancers (MPC) could provide important information as to the pathogenesis of human malignancies. Analysis of MPC using clinical databases has been performed, but little has been done using autopsy cases. Therefore, in this study, we first retrospectively analyzed MPC associated with endometrial and ovarian cancers using the Japan Autopsy Annual Database. Methods The Japan Autopsy Annual Database from 2002 to 2010 was established by the Japanese Society of Pathology, Tokyo, Japan. Among the 164?211 autopsy cases registered, 9142 were cases of primary cancers. Results The patients with endometrial cancer‐associated MPC did have a lower risk of harboring colorectal cancer (odds ratio [OR], 0.63; 95% confidence interval [CI], 0.45–0.89) but had a higher risk of ovarian cancer (OR, 3.15; 95% CI, 2.11–4.71). Those with ovarian cancer‐associated MPC had a lower risk of harboring gallbladder cancer including bile ductal cancer (OR, 0.47; 95% CI, 0.27–0.80) but a higher risk of harboring breast (OR, 1.69; 95% CI, 1.20–2.38) and endometrial cancers (OR, 3.48; 95% CI, 2.33–5.20). Conclusion Both endogenous and exogenous factors are associated with the incidence of MPC. Results of our present study based on Japanese Autopsy Base first demonstrated that female hormones had a strong influence on the incidence of MPC. This study also demonstrated that the analysis of MPC using an autopsy database could have advantages over clinical database analysis.
机译：摘要旨在对多发性癌症（MPC）的彻底分析可以提供对人类恶性肿瘤发病机制的重要信息。已经进行了使用临床数据库的MPC分析，但使用尸检案例已经很少。因此，在本研究中，我们首先回顾性地分析了使用日本尸检年度数据库的子宫内膜和卵巢癌相关的MPC。方法采用日本东京东京的日本病理学学会2002年至2010年日本尸检年度数据库。在164岁？211例尸检病例中，9142例是原发性癌症的病例。结果子宫内膜癌相关的MPC患者具有较低的含结肠直肠癌的风险较低（差异[或]，0.63; 95％置信区间[CI]，0.45-0.89）但具有更高的卵巢癌风险（或， 3.15; 95％CI，2.11-4.71）。卵巢癌相关的MPC的那些患有胆囊癌的风险较低，包括胆管癌（或0.47; 95％CI，0.27-0.80），但患乳房的风险较高（或1.69; 95％CI，1.20- 2.38）和子宫内膜癌症（或3.48; 95％CI，2.33-5.20）。结论内源性和外源性因素均与MPC的发生率有关。我们基于日本尸检基础的目前研究的结果首先证明了女性激素对MPC发病率产生了强烈影响。本研究还证明了使用尸检数据库的MPC分析可能具有优于临床数据库分析的优势。

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