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首页> 外文期刊>The Journal of Steroid Biochemistry and Molecular Biology >Androgen biosynthesis during minipuberty favors the backdoor pathway over the classic pathway: Insights into enzyme activities and steroid fluxes in healthy infants during the first year of life from the urinary steroid metabolome
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Androgen biosynthesis during minipuberty favors the backdoor pathway over the classic pathway: Insights into enzyme activities and steroid fluxes in healthy infants during the first year of life from the urinary steroid metabolome

机译：Minipuberty期间的雄激素生物合成有利于经典途径的后门路径：在尿原素代谢物的第一年生命的第一年期间，在健康婴儿的酶活性和类固醇通量见解

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The steroid profile changes dramatically from prenatal to postnatal life. Recently, a novel backdoor pathway for androgen biosynthesis has been discovered. However, its role remains elusive. Therefore, we investigated androgen production from birth to one year of life with a focus on minipuberty and on production of androgens through the backdoor pathway. Additionally, we assessed the development of the specific steroid enzyme activities in early life. To do so, we collected urine specimens from diapers in 43 healthy newborns (22 females) at 13 time points from birth to one year of age in an ambulatory setting, and performed in house GC MS steroid profiling for 67 steroid metabolites. Data were analyzed for androgen production through the classic and backdoor pathway and calculations of diagnostic ratios for steroid enzyme activities were performed. Analysis revealed that during minipuberty androgen production is much higher in boys than in girls (e.g. androsterone (An)), originates largely from the testis, (An(boys)-An(girls)) and uses predominantly the alternative backdoor pathway (An/Et; Delta 5 < Delta 4 lyase activity). Modelling of steroid enzyme activities showed age-related effects for 21-, 11-, 17-hydroxylase and P450 oxidoreductase activities as well as 3 p-hydroxysteroid dehydrogenase, 11 beta-hydroxylase type 1/2 and 5 alpha-reductase activities. Sex-related characteristics were found for 21-hydroxylase and 5 alpha-reductase activities. Overall, our study shows that androgen biosynthesis during minipuberty favors the backdoor pathway over the classic pathway. Calculations of specific diagnostic ratios for enzyme activities seem to allow the diagnosis of specific steroid disorders from the urinary steroid metabolome. (C) 2016 Elsevier Ltd. All rights reserved.
机译：类固醇型材从产前到产后寿命发生巨大变化。最近，已经发现了一种用于雄激素生物合成的新型后门途径。然而，其作用仍然难以捉摸。因此，我们从出生到一年的生命中调查了雄激素产量，并专注于微型途径和通过后门途径的雌激素的生产。此外，我们还评估了早期生命中特定类固醇酶活性的发展。为此，我们将尿液从43名健康新生儿（22名女性）的尿液中的尿液标本从出生于出生时间到年龄的一年，并在House GC MS类固醇分析中进行67种类固醇代谢物。通过经典的和后德途径分析数据进行雄激素产生，并进行类固醇酶活性的诊断比率。分析显示，在小型雄激素生产期间，男孩雄激素产量远高于女孩（例如androsterone（Androsterone（AN）），主要来自睾丸，（男孩）-an（女孩）），主要用途，主要是替代的后门路线（AN /等; Delta 5

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