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首页> 外文期刊>AIDS care. >Regional fat deposition and cardiovascular risk in HIV infection: the FRAM study.
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Regional fat deposition and cardiovascular risk in HIV infection: the FRAM study.

机译：HIV感染中的区域性脂肪沉积和心血管风险：FRAM研究。

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HIV-infected individuals are at increased risk for cardiovascular disease (CVD) and lipodystrophy, but the relationship between regional adipose tissue (AT) depots and CVD risk is not well described. We determined regional AT volumes and CVD risk in an analysis of 586 HIV-infected and 280 control FRAM study subjects using whole-body magnetic resonance imaging (MRI) and the Framingham Risk Score (FRS). Median FRS and FRS >10% were higher in HIV than control men (4.7% vs. 3.7%, p=0.0002; 16% vs. 4%, p<0.0001). HIV and control women had similarly low FRS (1.1% vs. 1.2%, p=0.91). In controls, total AT and all regional AT depots showed strong positive correlations with FRS (p<0.001) in men and weaker positive correlations in women. Greater visceral AT (VAT) and lower leg subcutaneous AT (SAT) volumes were associated with elevated FRS in HIV subjects with a trend for upper trunk SAT. Controls in the lowest quartile of leg SAT had the lowest FRS (1.5%), whereas HIV with similarly low leg SAT had the highest FRS (4.0%, p<0.001 vs. controls). Increased VAT is associated with CVD risk, but the risk is higher in HIV-infected individuals relative to controls at every level of VAT. Peripheral lipoatrophy (as measured by leg SAT) is associated with striking increased CVD risk in HIV-infected patients even after controlling for VAT, whereas low leg SAT is associated with low CVD risk in controls.
机译：受HIV感染的个体罹患心血管疾病（CVD）和脂肪营养不良的风险增加，但是并未很好地描述区域脂肪组织（AT）库与CVD风险之间的关系。我们使用全身磁共振成像（MRI）和弗雷明汉风险评分（FRS）对586名HIV感染者和280名对照FRAM研究对象进行了分析，从而确定了区域性AT量和CVD风险。 HIV中的FRS中位数和FRS> 10％高于对照组男性（4.7％比3.7％，p = 0.0002; 16％比4％，p <0.0001）。艾滋病毒和对照妇女的FRS较低（分别为1.1％和1.2％，p = 0.91）。在对照组中，男性的总AT和所有区域性AT仓库与FRS呈强正相关（p <0.001），而女性则呈较弱的正相关。较高的内脏AT（VAT）和小腿皮下AT（SAT）量与HIV受试者的FRS升高相关，并伴有上躯干SAT的趋势。腿SAT最低四分位数的对照组的FRS最低（1.5％），而腿SAT较低的HIV的FRS最高（4.0％，与对照组相比，p <0.001）。增值税增加与CVD风险相关，但是与感染各个级别增值税的对照组相比，感染HIV的个体的风险更高。即使在控制了增值税后，周围脂肪萎缩（通过腿部SAT测量）也与HIV感染患者的CVD风险显着增加相关，而低腿SAT与对照组的CVD风险较低相关。

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