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首页> 外文期刊>The journal of sexual medicine >Plasma Testosterone and Sexual Function in Southeast Asian Men Receiving Methadone and Buprenorphine Maintenance Treatment
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Plasma Testosterone and Sexual Function in Southeast Asian Men Receiving Methadone and Buprenorphine Maintenance Treatment

机译：血浆睾酮和性功能在东南亚男性接受美沙酮和丁丙诺啡维修治疗

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Abstract Background Methadone has been recognized as an effective maintenance treatment for opioid dependence. However, its use is associated with several complications, including sexual dysfunction in men. Aim To assess plasma testosterone and sexual function in Southeast Asian men on methadone maintenance treatment (MMT) or buprenorphine maintenance treatment (BMT). Methods 76 sexually active men on MMT (mean age?= 43.30 ± 10.32 years) and 31 men on BMT (mean age?= 41.87 ± 9.76 years) from a Southeast Asian community were evaluated using plasma total testosterone (TT) and prolactin levels, body mass index, social demographics, substance use measures, and depression severity scale. Outcomes Prevalence and associated factors of TT level lower than the reference range in men on MMT or BMT. Results More than 1 third of men (40.8%, n?= 31) on MMT had TT levels lower than the reference range, whereas 1 fourth of men (22.6%, n?= 7) on BMT did. At univariate analysis, MMT vs BMT (β?= 0.298, adjusted R 2 ?= 0.08, P ?= .02) and body mass index (β?=??0.23, adjusted R 2 ?= 0.12, P ?= .02) were associated with changes in TT after stepwise regression. There were no significant associations with age; Opiate Treatment Index Q scores for alcohol, heroin, stimulant, tobacco, or cannabis use and social functioning domain; education levels; hepatitis C status; and severity of depression. Prolactin level did not differ between the MMT and BMT groups. Clinical Implications The sex hormonal assay should be used regularly to check men on MMT. Strengths and Limitations This is the first study conducted in the Southeast Asian community. Our study was limited by the lack of a healthy group as the reference for serum levels of testosterone and prolactin. Conclusions The findings showed that plasma testosterone levels are lower in MMT than in BMT users. Hence, men who are receiving MMT should be screened for hypogonadism routinely in the clinical setting. Yee A, Loh HS, Danaee M, et?al. Plasma Testosterone and Sexual Function in Southeast Asian Men Receiving Methadone and Buprenorphine Maintenance Treatment. J Sex Med 2018;15:159–166.
机译：摘要背景美沙酮已被认为是阿片类药物依赖的有效维护治疗。然而，它的使用与几种并发症有关，包括男性的性功能障碍。目的在于评估血浆睾酮和性功能在东南亚男性对美沙酮维持治疗（MMT）或Buprenorphine维持治疗（BMT）。方法使用血浆总睾丸激素（TT）和催乳素水平评估来自东南亚社区的BMT（平均年龄）和31名男性（平均年龄）和31名男性（平均年龄？= 41.87±9.76岁）。体重指数，社会人口统计，物质使用措施和抑郁症严重等级。结果患病率和TT水平的相关因素低于MMT或BMT的男性参考范围。结果MMT的1多三分之一（40.8％，N？= 31）的MMT具有低于参考范围的TT水平，而1次男性（22.6％，N？= 7）。在单变量分析中，MMT VS BMT（β= 0.298，调整后R 2？= 0.08，P？= .02）和体重指数（β？=Δ0.23，调整R 2？= 0.12，P？= 0.02 ）与逐步回归后TT的变化有关。没有重要的协会与年龄; Apiate治疗指标q酒精，海洛因，兴奋剂，烟草或大麻使用和社会运作领域的分数;教育水平;丙型肝炎状态;和抑郁症的严重程度。 MMT和BMT组之间的催乳素水平没有区别。临床意义性激素测定应定期使用以检查MMT的男性。优势和局限性这是东南亚社区进行的第一项研究。我们的研究受到缺乏健康组作为血清睾酮和催乳素水平的参考的限制。结论发现表明，MMT的血浆睾酮水平低于BMT用户。因此，在临床环境中，应常规地筛选接受MMT的男性。 yee a，loh hs，danaee m，et？al。血浆睾酮和性功能在东南亚男性接受美沙酮和丁丙诺啡维修治疗。 J SEX MED 2018; 15：159-166。

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