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首页> 外文期刊>The journal of sexual medicine >Effect of Penile Traction and Vacuum Erectile Device for Peyronie’s Disease in an Animal Model
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Effect of Penile Traction and Vacuum Erectile Device for Peyronie’s Disease in an Animal Model

机译：阴茎牵引与真空勃起装置对佩雷尼氏病的影响动物模型疾病

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Abstract Background Penile traction therapy with the use of a traction device (TD) or vacuum erectile device (VED) has been studied as local modalities for Peyronie’s disease (PD). Aim To identify changes of penile curvature, erectile function, and possible cellular and molecular mechanisms between the TD and VED in a rat model of PD. Methods Peyronie’s plaque was induced in 30 adult male rats. Then, rats were randomly divided into control (PD without treatment), VED, and TD groups. In the VED group, vacuum pressure was applied to the cylinder to induce penile engorgement inside the cylinder for 1 minute. The penis was allowed to deflate completely for another 1 minute. This was repeated for five cycles (inflate and deflate). In the TD group, the rat penis was straightened by a suspended tension gauge at the same tension by clamping the prepuce. This was performed three times per day at 20 minutes per session, with 5-minute intervals between sessions. The entire treatment duration was 4 weeks. Outcomes Penile curvature, intracavernosal pressure, and mean arterial pressure were measured. Immunohistochemistry for α-smooth muscle actin, transforming growth factor-β1 and mothers against decapentaplegic homolog 2/3 were performed. Results The TD and VED groups had less penile curvature compared with the control group (15.3 ± 5.3° for TD, 28.4 ± 6.8° for VED, 38.6 ± 10.5° for control; P P P P Clinical Translation Various benefits can be observed with the TD and VED for the treatment of PD. Strengths and Limitations This study explored the mechanism and benefits of TD and VED therapies for the treatment of PD. The rat model might not represent the human condition. Conclusion Penile traction therapy with the TD or VED is beneficial to decrease penile curvature in animal models of PD. The underlying mechanism could be related to antiapoptosis, antifibrosis, and smooth muscle preservation. Lin H, Liu C, Wang R. Effect of Penile Traction and Vacuum Erectile Device for Peyronie’s Disease in an Animal Model. J Sex Med 2017;14:1270–1276 .
机译：摘要背景，使用牵引装置（TD）或真空勃起装置（VED）的牵引牵引疗法已被研究为PEYRONIE疾病（PD）的局部方式。目的识别PD大鼠大鼠模型中TD和TD和VED之间的阴茎曲率，勃起功能和可能的细胞和分子机制的变化。方法采用PEYRONIE的斑块在30名成年雄性大鼠中诱导。然后，将大鼠随机分为对照（没有处理的PD），VED和TD组。在VED组中，将真空压力施加到气缸上，以诱导气缸内的阴茎结合1分钟。允许阴茎完全放气1分钟。这重复了五个循环（充气和放气）。在Td组中，通过夹紧前置的悬浮率，通过悬浮的张力计伸直大鼠阴茎。每次会议每天进行每天进行三次，在会话之间有5分钟的间隔。整个治疗持续时间为4周。测量结果阴茎曲率，胞内压力和平均动脉压。进行免疫组织化学，进行α-平滑肌肌动蛋白，进行转化生长因子-β1和针对脱尾屈曲同源物2/3的母亲。结果TD和VED组与对照组相比具有较少的阴茎曲率（用于TD 15.3±5.3°，对照38.4±6.8°，控制38.6±10.5°; PPPP临床翻译可以用TD和VED观察各种益处用于治疗PD。本研究探讨了TD和VED疗法治疗PD的机制和益处。大鼠模型可能不代表人体状况。结论与TD或VED的阴茎牵引疗法有益，有利于降低PD的动物模型中的阴茎曲率。潜在的机制可能与抗痘病，抗灰度和平滑肌保存有关。林H，刘C，王R.对动物模型中PEYRONIE疾病的阴茎牵引和真空勃起装置的影响。J 2017年性别医学; 14：1270-1276。

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