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首页> 外文期刊>The journal of sexual medicine >Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans
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Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans

机译：手淫对高潮刺激了人类的内胆蛋白2- arachidonlgycerol的释放

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Abstract Background Endocannabinoids are critical for rewarding behaviors such as eating, physical exercise, and social interaction. The role of endocannabinoids in mammalian sexual behavior has been suggested because of the influence of cannabinoid receptor agonists and antagonists on rodent sexual activity. However, the involvement of endocannabinoids in human sexual behavior has not been studied. Aim To investigate plasma endocannabinoid levels before and after masturbation in healthy male and female volunteers. Outcomes Plasma levels of the endocannabinoids 2-arachidonoylglycerol (2-AG), anandamide, the endocannabinoid-like lipids oleoyl ethanolamide and palmitoyl ethanolamide, arachidonic acid, and cortisol before and after masturbation to orgasm. Methods In study 1, endocannabinoid and cortisol levels were measured before and after masturbation to orgasm. In study 2, masturbation to orgasm was compared with a control condition using a single-blinded, randomized, 2-session crossover design. Results In study 1, masturbation to orgasm significantly increased plasma levels of the endocannabinoid 2-AG, whereas anandamide, oleoyl ethanolamide, palmitoyl ethanolamide, arachidonic acid, and cortisol levels were not altered. In study 2, only masturbation to orgasm, not the control condition, led to a significant increase in 2-AG levels. Interestingly, we also found a significant increase of oleoyl ethanolamide after masturbation to orgasm in study?2. Clinical Translation Endocannabinoids might play an important role in the sexual response cycle, leading to possible implications for the understanding and treatment of sexual dysfunctions. Strengths and Limitations We found an increase of 2-AG through masturbation to orgasm in 2 studies including a single-blinded randomized design. The exact role of endocannabinoid release as part of the sexual response cycle and the biological significance of the finding should be studied further. Cannabis and other drug use and the attainment of orgasm were self-reported in the present study. Conclusion Our data indicate that the endocannabinoid 2-AG is involved in the human sexual response cycle and we hypothesize that 2-AG release plays a role in the rewarding consequences of sexual arousal and orgasm. Fuss J, Bindila L, Wiedemann K, et?al. Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans. J Sex Med 2017;14:1372–1379.
机译：摘要背景Endocannabinoids对于奖励饮食，体育锻炼和社会互动等行为至关重要。由于大麻素受体激动剂和拮抗剂对啮齿动物性活动的影响，提出了EndiNocannabinoids在哺乳动物性行为中的作用。然而，尚未研究人体性行为中的内胆蛋白酶。目的是在健康男性和女性志愿者手淫之前和之后探讨血浆内胆蛋白水平。结局血浆蛋白2- arachidonoylgycerol（2-Ag），Anandandide，异甘油蛋白样脂质和棕榈酰胺和棕榈酰磺酰胺，花生素酸和皮质醇前后的性高潮，血管醇乙醇酰胺和皮质醇的血浆水平。研究中的方法1，在手淫前后测量内炎素醇和皮质醇水平，对高潮进行测量。在研究2中，使用单一盲化，随机的2会话交叉设计与控制条件进行手淫。研究结果1，对高潮的手淫显着增加了内炎素2-AG的血浆水平，而不酰胺，油酰乙酰胺，棕榈酰乙醇酰胺，花生酸和皮质醇水平未被改变。在研究2中，只有手淫到性高潮，而不是控制条件，导致2-AG水平的显着增加。有趣的是，我们还发现在研究中手淫后的Oleyl乙醇酰胺的显着增加？2。临床翻译内皮蛋白可能在性响应周期中发挥重要作用，从而产生对性功能障碍的理解和治疗可能的影响。在2项研究中，我们发现通过手淫增加2-AG的强度和限制，包括单一盲化随机设计。 Endocannabinoid释放作为性响应周期的一部分的确切作用以及应进一步研究发现的生物学意义。在本研究中，大麻和其他药物使用和可高潮的达到性质是自我报告的。结论我们的数据表明，Endocannabinoid 2-AG参与人类性响应周期，我们假设2-AG释放在性唤起和性高潮的奖励后果中起着作用。大惊小怪J，Bindila L，Wiedemann K，et？al。手淫对高潮刺激了人类内胚老植物2-甲脒酰基甘油的释放。 J SEX MED 2017; 14：1372-1379。

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