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首页> 外文期刊>AIDS care. >Appropriateness of antiretroviral therapy in clients of an HIV/AIDS case management organization.
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Appropriateness of antiretroviral therapy in clients of an HIV/AIDS case management organization.

机译：艾滋病毒/艾滋病病例管理组织的客户应适当使用抗逆转录病毒疗法。

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We sought to assess appropriateness of antiretroviral therapy (ART) reported by clients of an HIV/AIDS case management organization and identify variables associated with appropriate ART receipt. A total of 295 such clients were mailed a survey asking them to identify antiretroviral medications they were taking. Of them 220 (75%) returned surveys; 201 (93%) were taking antiretrovirals. Of these, 159 were on appropriate and 36 on inappropriate ART, as determined by guidelines created by the CDC, the International AIDS Society (USA Panel), and the Panel on Clinical Practices for Treatment of HIV Infection. In unadjusted analyses, age, sex, race, sexual orientation, history of injection drug use, history of sexual risk, and HIV knowledge were associated (p< or =0.10) with appropriate ART and entered into one of two logistic regression models. The first model indicated that women (p=0.003) and heterosexuals (p=0.001) were less likely to receive appropriate ART than men and gay/bisexuals (and variables interacted, p=0.001). HIV knowledge--a proxy indicator determined by self-report of a CD4 cell count and viral load--was added to variables retained in first model to create a second model. Only sexual orientation was retained in this second model (p=0.02, in the same direction as in the first model), and those with less versus more HIV knowledge (p=0.04) were found to be less likely to receive appropriate ART (and variables interacted, p=0.04). Findings suggest that heterosexual men are less likely than women who, in turn, are less likely than gay/bisexual men to receive appropriate ART. HIV-related knowledge appears to increase likelihood of receiving appropriate ART and it attenuates the effect of sex.
机译：我们试图评估艾滋病毒/艾滋病病例管理组织的客户报告的抗逆转录病毒疗法（ART）的适用性，并确定与适当ART收据相关的变量。总共295位此类客户被邮寄了一项调查，要求他们确定所服用的抗逆转录病毒药物。其中220（75％）个返回了调查; 201人（占93％）正在服用抗逆转录病毒药。根据疾病预防控制中心，国际艾滋病协会（美国小组）和治疗艾滋病毒感染的临床实践小组制定的指南，其中有159例是适当的，有36例是不适当的ART。在未经校正的分析中，将年龄，性别，种族，性取向，注射毒品史，性危险史和HIV知识与适当的抗逆转录病毒疗法相关联（p <或= 0.10），并输入两个逻辑回归模型之一。第一个模型表明，与男性和男同性恋/双性恋者相比，女性（p = 0.003）和异性恋者（p = 0.001）接受适当抗逆转录病毒治疗的可能性较小（且变量相互影响，p = 0.001）。 HIV知识-一种通过CD4细胞计数和病毒载量的自我报告确定的替代指标-被添加到第一个模型中保留的变量中以创建第二个模型。在第二个模型中仅保留了性取向（p = 0.02，与第一个模型中的方向相同），并且发现HIV知识较少或较多的人（p = 0.04）被发现接受适当抗病毒治疗的可能性较小（并且变量相互影响，p = 0.04）。研究结果表明，异性恋男性比女性反而接受同种抗逆转录病毒疗法的可能性要低于男同性恋/双性恋男性。与艾滋病毒有关的知识似乎增加了接受适当抗病毒治疗的可能性，并且削弱了性行为的影响。

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