...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS care. >Differential improvement in survival among patients with AIDS after the introduction of HAART.
【24h】

Differential improvement in survival among patients with AIDS after the introduction of HAART.

机译：引入HAART后，艾滋病患者的生存率有所提高。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We explored changes in the survival of patients with AIDS (PWA) according to the availability of antiretroviral drugs (1994-2002). We tested whether changes in the hazard ratio of progression to death (HR) have been homogeneous among various groups of PWA. We included 4158 PWA diagnosed in Paris, notified to the French National Surveillance Institute by 2002. Four calendar periods were defined: monotherapy (1994-95), bitherapy-HAART transition (1996), early HAART (1997-99), late HAART (2000-October 2002). HR were calculated with Cox models, including the calendar period, modelled as a time dependent covariate. Models were stratified by age, transmission category, CD4 cell count, and AIDS-defining illnesses (ADI) group. Cumulative survival at 60 months increased from 44.0% (before July 1996) to 75.6% (after July 1996) and median survival increased from 31.9 months to >76 months. Adjusted HR reached a minimum in the late HAART period (HR 0.22, 95% CI: 0.19-0.26). No difference in the decrease of the HR has been found by age. HR decreased and was marked during the late HAART period across all HIV transmission categories, including intravenous drug use. HR decreased significantly for all ADIs groups, including tumours. Among PWA diagnosed with tuberculosis, the HR decreased significantly only in the late HAART period. HR decrease was stronger for PWA with a CD4 cell count < or =200/mm(3). Substantial improvements in survival after the introduction of HAART were found for all PWA but varied by specific ADIs and the degree of immunosuppression.
机译：我们根据抗逆转录病毒药物的供应情况（1994-2002年）探讨了艾滋病患者（PWA）生存率的变化。我们测试了各组PWA中病死率（HR）危险比的变化是否均一。我们纳入了在巴黎诊断出的4158个PWA，并于2002年通知法国国家监视学会。定义了四个日历周期：单一疗法（1994-95），双向疗法-HAART过渡（1996），早期HAART（1997-99），晚期HAART（ 2000年-2002年10月）。 HR是用Cox模型（包括日历周期）计算出来的，并建模为时间相关协变量。根据年龄，传播类别，CD4细胞计数和AIDS定义疾病（ADI）组对模型进行分层。 60个月的累积生存率从44.0％（1996年7月之前）增加到75.6％（1996年7月之后），中位生存期从31.9个月增加到> 76个月。在HAART后期，调整后的HR达到最小值（HR 0.22，95％CI：0.19-0.26）。 HR的降低没有发现年龄差异。在所有HIV传播类别（包括静脉吸毒）的HAART后期，HR下降并显着。所有ADIs组，包括肿瘤，HR均显着降低。在诊断为肺结核的PWA中，HR仅在HAART晚期才显着下降。对于CD4细胞计数<或= 200 / mm（3）的PWA，HR下降更明显。引入HAART后，发现所有PWA的生存率都有实质性改善，但随特定ADI和免疫抑制程度的不同而不同。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号