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首页> 外文期刊>AIDS care. >The societal burden of HIV/AIDS in Northern Italy: an analysis of costs and quality of life.
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The societal burden of HIV/AIDS in Northern Italy: an analysis of costs and quality of life.

机译：意大利北部艾滋病毒/艾滋病的社会负担：对成本和生活质量的分析。

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This study aims to measure the direct and indirect costs of HIV/AIDS care and quality of life (QoL) of HIV-infected patients in Northern Italy. We conducted a prospective cohort study over 12 months, enrolling a sample of 121 patients with HIV infection from two cities in Northern Italy. Patients were surveyed at baseline and were followed-up at 6 and 12 months. To assess the relationship between costs and stage of disease, patients were categorized into three groups at baseline: "No HAART" (asymptomatic and never before on highly active antiretroviral therapy (HAART)), "Stable HAART" (HAART with mild HIV infection and no prior opportunistic infections) and "HAART failure" (primary HAART regimen was altered because of severe side effects or immunological failure). Direct medical costs were based on utilization of (day) hospital admissions, diagnostic procedures, laboratory tests, clinic visits, consultations and antiretroviral drug use. Indirect costs included production losses due to absence from work, reduced productivity at work and reduced unpaid labour participation. QoL was assessed by visual analogue scale. Parametric regression was used to estimate the expected value and the standard deviation of annual costs per patient. The expected value of total annual costs was 1818 euros and 9820 euros and 12,332 euros, for groups "No HAART", "Stable HAART" and "HAART failure" respectively. We estimated annual expected earnings as 14,994 euros and 10,811 euros and 9820 euros for the same respective groups. The expected value of QoL on a scale of 0-1 in these same patient groups was 0.80, 0.78 and 0.64. We conclude that indirect costs contribute substantially to total costs and are comparable in magnitude to the direct costs excluding antiretroviral drugs. The costs of inpatient care in our cohort were almost negligible compared to total costs. Despite being in treatment, many patients were still gainfully employed and generated substantial expected annual earnings.
机译：这项研究旨在衡量意大利北部艾滋病毒/艾滋病治疗的直接和间接费用以及感染艾滋病毒的患者的生活质量（QoL）。我们进行了为期12个月的前瞻性队列研究，从意大利北部两个城市招募了121名HIV感染患者。在基线时对患者进行了调查，并在6和12个月时进行了随访。为了评估费用与疾病分期之间的关系，将患者分为三类：“无HAART”（无症状且从未接受过高活性抗逆转录病毒疗法（HAART）），“稳定HAART”（有轻度HIV感染的HAART和没有先前的机会性感染）和“ HAART失败”（由于严重的副作用或免疫学失败而改变了主要的HAART方案）。直接医疗费用是基于（每天）入院，诊断程序，实验室检查，诊所就诊，咨询和使用抗逆转录病毒药物的使用情况。间接成本包括因缺勤而造成的生产损失，工作效率降低和无偿劳动参与减少。生活质量通过视觉模拟量表进行评估。使用参数回归来估计期望值和每位患者每年费用的标准差。 “无HAART”，“稳定HAART”和“ HAART失败”组的年度总成本的期望值分别为1818欧元，9820欧元和12332欧元。我们估计同一集团的年度预期收益分别为14,994欧元，10,811欧元和9820欧元。在这些相同患者组中，QoL在0-1量表上的预期值为0.80、0.78和0.64。我们得出的结论是，间接成本在总成本中占很大比重，在规模上与不包括抗逆转录病毒药物的直接成本相当。与总费用相比，我们队列中的住院护理费用几乎可以忽略不计。尽管正在接受治疗，但许多患者仍在从事有收益的工作，并产生了可观的预期年收入。

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