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Late diagnosis of HIV infection at two academic medical centers: 1994-2004.

机译:1994年至2004年在两个学术医学中心对HIV感染的晚期诊断。

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Over the last decade, there has been increased attention to the role of earlier HIV testing in the United States. Our objective was to determine if this has translated into changes in the proportion of inpatients with advanced disease at the time of initial HIV diagnosis. We identified inpatients discharged with a new diagnosis of HIV infection or AIDS between 1994 and 2004 at two academic medical centers. We examined trends in initial CD4 count at diagnosis over three time periods: 1994-1996, 1997-2000 and 2001-2004. Between 1994 and 2004, 235 inpatients were newly diagnosed with HIV infection or AIDS in the two centers. For the 217 patients with available CD4 count data, the median initial CD4 count was 41/microl (interquartile range 19-138/microl). Of the 217 patients, 184(85%) had CD4 < or =200/microl and 119/217 (55%) had CD4 < or =50/microl. There were no significant differences in median CD4 count by time period. A large majority of inpatients with newly diagnosed HIV infection at two academic medical centers between 1994 and 2004 had signs of advanced immunodeficiency. Over this recent 11-year period there was no evidence that inpatients with a new HIV diagnosis were identified at earlier stages of disease.
机译:在过去的十年中,在美国,人们越来越关注早期HIV检测的作用。我们的目标是确定在最初诊断HIV时,这是否已转变为晚期疾病住院患者的比例变化。我们确定了1994年至2004年之间在两个学术医疗中心出院的艾滋病毒感染或艾滋病新诊断患者。我们研究了1994-1996、1997-2000和2001-2004这三个时间段的诊断时CD4初始计数趋势。在1994年至2004年之间,两个中心新诊断出235名住院病人患有HIV感染或艾滋病。对于217位具有可用CD4计数数据的患者,初始CD4计数中位数为41 /微升(四分位间距19-138 /微升)。在217位患者中,184(85%)的CD4 <或= 200 / microl,而119/217(55%)的CD4 <或= 50 / microl。各时段CD4计数中位数无显着差异。在1994年至2004年之间,两个学术医学中心的大部分新近诊断出HIV感染的住院患者都有晚期免疫缺陷的迹象。在最近的11年中,没有证据表明在疾病的早期发现了新的HIV诊断住院病人。

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