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首页> 外文期刊>The ocular surface >Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases
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Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases

机译：高分辨率光学相干断层扫描在诊断眼表面鳞状肿瘤诊断中的作用

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Abstract Purpose Coexistence of an ocular surface disease can mask the typical features of ocular surface squamous neoplasia (OSSN). The purpose of this study was to evaluate high resolution optical coherence tomography (HR-OCT) as an adjunct in the detection and differentiation of OSSN within coexisting ocular surface pathologies. Methods Retrospective study of 16 patients with ocular surface disease and lesions suspicious for OSSN that were evaluated with HR-OCT. HR-OCT images of the lesions were taken to look for evidence of OSSN. Biopsies were performed in all cases, and the HR-OCT findings were compared to the histological results. Results Of the 16 patients with OSSN and a coexisting ocular surface disease, 12 were found to have OSSN by HR-OCT and all were subsequently confirmed by biopsy. Two patients had OSSN with rosacea, one with pingueculum, two within pterygia, one with Salzmann’ nodular degeneration, six with limbal stem cell deficiency (LSCD)/scarring. In all 12 cases HR-OCT images revealed classical findings of hyper-reflective, thickened epithelium and an abrupt transition from normal to abnormal epithelium. OSSN was ruled out by HR-OCT in four cases (2 Salzmann's, 1 mucous membrane pemphigoid, and 1 LSCD). Negative findings were confirmed by biopsy. HR-OCT was used to follow resolution of the OSSN in positive cases, and it detected recurrence in 1 case. Conclusions While histopathology is the gold standard in the diagnosis of OSSN, HR-OCT can be used to noninvasively detect the presence of OSSN in patients with coexisting ocular conditions.
机译：眼部表面疾病的摘要目的共存可以掩盖眼表面鳞状肿瘤肿瘤（OSSN）的典型特征。本研究的目的是评估高分辨率光学相干断层扫描（HR-OCT）作为在共存眼表面病理中检测和分化的辅助处的辅助。方法对HR-OCT评估的16例眼表面疾病和病变怀疑患者的回顾性研究。 HR-OCT图像的病变被认为寻找OSSN的证据。在所有情况下进行活组织检查，将HR-OCT发现与组织学结果进行比较。结果16例OSSN患者和共存眼表面疾病，12例被HR-OCT的OSSN患者，随后通过活组织检查证实了所有。两名患者有OSSN与Rosacea，一种有PingueCulum，翼状胬肉中的两个，一个配有Salzmann的结节性退化，六个具有恒星干细胞缺乏（LSCD）/疤痕。在所有12例中，HR-OCT图像揭示了超反射，增稠的上皮的古典发现和从正常上皮的突然转变。 OSSN在四种情况下由HR-OCT排除（2例Salzmann，1个粘膜膜斑阴性，1 LSCD）。通过活组织检查证实了阴性结果。 HR-OCT用于追随阳性病例中OSSN的分辨率，并且在1例中检测到复发。结论虽然组织病理学是核心诊断中的黄金标准，但HR-OCT可用于非侵入地检测患者在共存眼部条件下的OSSN的存在。

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