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首页> 外文期刊>AIDS care. >Operating characteristics of carbohydrate-deficient transferrin (CDT) for identifying unhealthy alcohol use in adults with HIV infection.
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Operating characteristics of carbohydrate-deficient transferrin (CDT) for identifying unhealthy alcohol use in adults with HIV infection.

机译：碳水化合物不足的转铁蛋白（CDT）的操作特征，用于识别HIV感染成人中不健康的酒精使用。

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Unhealthy alcohol use (the spectrum of risky use through dependence) is common in HIV-infected persons, yet it can interfere with HIV medication adherence, may lower CD4 cell count, and can cause hepatic injury. Carbohydrate-deficient transferrin (CDT), often measured as %CDT, can detect heavy drinking but whether it does in people with HIV is not well established. We evaluated the operating characteristics of %CDT in HIV-infected adults using cross-sectional data from 300 HIV-infected adults with current or past alcohol problems. Past 30-day alcohol consumption was determined using the Timeline Followback (TLFB), a validated structured recall questionnaire, as the reference standard. Sensitivity and specificity of %CDT (at manufacturer's cut-off point of 2.6%) for detecting both "at-risk" (>/=4 drinks in a day or >7 drinks per week for women, >/=5 drinks in a day or >14 per week for men) and "heavy" drinking (>/=4 drinks in a day for women, >/=5 drinks in a day for men on at least seven days) were calculated. Receiver operating characteristic (ROC) curves were estimated to summarize the diagnostic ability of %CDT for distinguishing "at risk" and "heavy" levels of drinking. Exploratory analyses that stratified by gender and viral hepatitis infection were performed. Of 300 subjects, 103 reported current consumption at at-risk sensitivity of %CDT was 28% (95% confidence interval (CI) 19%, 37%), specificity 90% (95% CI 86%, 94%); area under the ROC curve (AUC) was 0.59. For "heavy" drinking, sensitivity was 36% (95% CI 22%, 50%), specificity 88% (95% CI 84%, 92%); AUC was 0.60. Sensitivity appeared lower among women and those with viral hepatitis; specificity was similar across subgroups. Among HIV-infected adults, %CDT testing yielded good specificity, but poor sensitivity for detecting at-risk detecting unhealthy alcohol use in this population.
机译：在HIV感染者中不健康的饮酒（通过依赖来进行危险的使用）是很常见的，但它会干扰HIV药物的依从性，可能会降低CD4细胞的数量，并可能导致肝损伤。缺乏碳水化合物的转铁蛋白（CDT），通常以％CDT来衡量，可以检测出大量饮酒，但对于HIV感染者是否可以大量饮酒，尚无定论。我们使用来自300名患有当前或过去饮酒问题的HIV感染成年人的横断面数据，评估了％CDT在HIV感染成年人中的操作特征。使用经过验证的结构化召回问卷时间表（Timeline Followback）（TLFB）作为参考标准，确定过去30天的饮酒量。 ％CDT（在制造商的分界点为2.6％时）对于检测“高风险”（每天> / = 4杯或女性每周> 7杯，> / = 5杯）的敏感性和特异性每天或男性每周> 14喝酒）和“大量”饮酒（女性每天> / = 4杯酒，男性至少在7天每天> / = 5杯酒）。估计接受者的工作特征（ROC）曲线可总结％CDT区分饮酒“高危”和“重度”水平的诊断能力。进行了按性别和病毒性肝炎感染分层的探索性分析。在300名受试者中，有103名报告的在危险性为％CDT时的电流消耗为28％（95％置信区间（CI）19％，37％），特异性为90％（95％CI 86％，94％）; ROC曲线下的面积（AUC）为0.59。对于“重度”饮酒，敏感性为36％（95％CI 22％，50％），特异性为88％（95％CI 84％，92％）; AUC为0.60。妇女和病毒性肝炎患者的敏感性降低。各亚组之间的特异性相似。在受HIV感染的成年人中，％CDT检测产生了良好的特异性，但在该人群中检测高危检测不健康饮酒的敏感性较低。

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