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Sensitivity and specificity of clinician administered screening instruments in detecting depression among HIV-positive individuals in Uganda

机译：临床医生使用的筛查仪器在乌干达检测HIV阳性人群中的抑郁症的敏感性和特异性

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Depressive disorders are highly prevalent in Africa where diseases such as HIV/AIDS are common. The aim of this study was to assess the validity of commonly used depression screening instruments in a setting characterized by low literacy, where patients may not be able to self-administer depression scales. We explored the validity of the Patient Health Questionaire-9 (PHQ-9), Centre for Epidemiological Surveys for Depression (CES-D), and the Kessler-10 (K-10), using the Mini International Neuropsychiatric Instrument (MINI) as a gold standard in 368 persons living with HIV/AIDS (PLWHA) in Uganda. The shorter versions of the K-10 and PHQ-9 were extracted to assess their performance in comparison to the longer versions. We used STATA 11.2 to analyze the data. The prevalence of a MINI defined depression in this patient sample was 17.4%. The three instruments all performed well, with areas under the curve (AUC) ranging from 0.82 to 0.96. The PHQ-9 showed the best performance characteristics with an AUC of 0.96, a sensitivity of 91.6%, and specificity 81.2%. The extracted versions performed more modestly. All three instruments showed good properties as screening tools; the PHQ-9 has particularly high sensitivity and specificity, and so can be considered useful for screening HIV-positive patients for depression.
机译：在非洲，艾滋病等疾病很普遍，抑郁症非常普遍。这项研究的目的是在识字率较低的情况下评估常用的抑郁症筛查工具的有效性，在这种情况下患者可能无法自行使用抑郁量表。我们使用迷你国际神经精神病学仪器（MINI）作为研究对象，探讨了患者健康问卷9（PHQ-9），抑郁症流行病学调查中心（CES-D）和凯斯勒10（K-10）的有效性。乌干达368名艾滋病毒/艾滋病感染者的黄金标准。提取了较短版本的K-10和PHQ-9，以评估其与较长版本的性能。我们使用STATA 11.2来分析数据。在该患者样品中，MINI定义的抑郁症患病率为17.4％。三种仪器均表现良好，曲线下面积（AUC）为0.82至0.96。 PHQ-9表现出最佳的性能特征，AUC为0.96，灵敏度为91.6％，特异性为81.2％。提取的版本执行得比较适度。三种仪器均具有良好的筛选工具性能。 PHQ-9具有特别高的敏感性和特异性，因此可用于筛查HIV阳性患者是否患有抑郁症。

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