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首页> 外文期刊>AIDS care. >Active cocaine use is associated with lack of HIV-1 virologic suppression independent of nonadherence to antiretroviral therapy: Use of a rapid screening tool during routine clinic visits
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Active cocaine use is associated with lack of HIV-1 virologic suppression independent of nonadherence to antiretroviral therapy: Use of a rapid screening tool during routine clinic visits

机译：积极使用可卡因与缺乏抗逆转录病毒疗法无关的HIV-1病毒学抑制有关：在常规门诊期间使用快速筛查工具

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Clarifying the relationship between illicit drug use and HIV-1 virologic suppression requires characterization of both illicit drug use activity and adherence to antiretroviral therapy (ART). We developed a rapid clinical questionnaire to assess prior 7-day illicit drug use and ART adherence in a cross-sectional study among 1777 HIV-infected persons in care. Of these, 76% were male, 35% were African-American, and 8% reported injection drug use as their probable route of HIV-1 infection. Questionnaire-reported frequencies of cocaine and marijuana use within the previous 7 days were 3.3% and 12.1%, respectively. Over three quarters (77.8%) of participants were on ART, of whom 69.7% had HIV-1 virologic suppression (HIV-1 RNA<48 copies/mL). Univariate analyses revealed that compared to no use, cocaine and marijuana use were both associated with missed ART doses (P<0.01). Multivariable logistic regression analysis adjusting for nonadherence demonstrated that cocaine use was independently associated with failing to achieve virologic suppression (adjusted odds ratio (aOR): 0.46; 95% confidence interval (95% CI): 0.22-0.98) but marijuana use was not (aOR: 1.08; 95% CI: 0.72-1.62). This result strengthens the evidence of a direct effect of cocaine on virologic control, independent of nonadherence to ART. ? 2013
机译：澄清非法药物使用与HIV-1病毒学抑制之间的关系需要同时描述非法药物使用活性和对抗逆转录病毒疗法（ART）的依从性。在一项涉及1777名HIV感染者的横断面研究中，我们开发了一项快速的临床调查问卷，以评估先前7天的非法药物使用和抗逆转录病毒疗法的依从性。其中，76％是男性，35％是非裔美国人，8％报告称注射毒品是他们可能感染HIV-1的途径。在过去7天内，问卷调查报告的可卡因和大麻使用频率分别为3.3％和12.1％。超过四分之三（77.8％）的患者接受抗逆转录病毒疗法，其中69.7％的患者接受了HIV-1病毒学抑制（HIV-1 RNA <48拷贝/ mL）。单因素分析显示，与不使用可卡因和大麻相比，可卡因和大麻的使用均与错过的抗逆转录病毒药物剂量相关（P <0.01）。调整了不依从性的多变量logistic回归分析表明，可卡因的使用与未能实现病毒学抑制作用独立相关（调整的优势比（aOR）：0.46; 95％的置信区间（95％CI）：0.22-0.98），而大麻的使用却没有（ aOR：1.08; 95％CI：0.72-1.62）。该结果加强了可卡因对病毒控制的直接作用的证据，而与不坚持抗逆转录病毒疗法无关。 ？ 2013年

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