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Frequency and correlates of anxiety and mood disorders among TB- and HIV-infected Zambians

机译：结核病和艾滋病毒感染的赞比亚人焦虑和情绪障碍的发生频率及其相关性

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摘要

We determined the frequency and correlates of current common mental disorders (CMDs) in a consecutive series of 649 adult patients with human immunodeficiency virus (HIV), tuberculosis (TB) or both receiving treatment at 16 primary health care centres across Zambia. Data on socio-demographic variables, clinical disease features, anxiety and mood disorders were collected. The frequency of any anxiety disorder (AD) was 30.8% and major depressive disorder (MDD) 11.3%. Although differences by disease group did not reach statistical significance, rates of suicidality (34.8%) and panic disorder (4.1%) were highest for the TB-HIV group (n = 269), while rates of generalised AD (13.3%), obsessive compulsive disorder (7.6%), posttraumatic stress disorder (7.4%) and any AD (37.8%) were highest for the HIV group (n = 149). Female gender (p = 0.004) predicted any current AD as well as current suicidality (p = 0.009), while lower education status (p < 0.001) predicted current MDD. World Health Organisation (WHO) clinical staging and antiretroviral treatment status were not significantly associated with MDD or anxiety in the HIV and co-infected groups. This study indicates the importance of early identification of CMDs in TB, HIV and co-infected patients, especially women and uneducated patients, newly initiated on treatment in primary care settings.
机译：我们确定了在赞比亚的16个初级卫生保健中心连续进行的649例人类免疫缺陷病毒（HIV），肺结核（TB）或两者均接受治疗的成年患者中，当前常见精神障碍（CMD）的发生频率和相关性。收集有关社会人口统计学变量，临床疾病特征，焦虑和情绪障碍的数据。焦虑症（AD）的发生率为30.8％，重度抑郁症（MDD）的发生率为11.3％。尽管各疾病组之间的差异没有统计学意义，但TB-HIV组的自杀率（34.8％）和恐慌症（4.1％）最高（n = 269），而广义AD的发生率（13.3％）为强迫症HIV组的强迫症（7.6％），创伤后应激障碍（7.4％）和任何AD（37.8％）最高（n = 149）。女性（p = 0.004）可以预测当前的AD以及当前的自杀倾向（p = 0.009），而较低的学历（p <0.001）可以预测当前的MDD。世界卫生组织（WHO）的临床分期和抗逆转录病毒治疗状况与HIV和合并感染组的MDD或焦虑症无显着相关性。这项研究表明，在初级保健机构中新近开展的结核病，艾滋病毒和合并感染患者，特别是妇女和未受教育的患者，尽早识别CMD的重要性。

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