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首页> 外文期刊>The Journal of toxicological sciences >Effect of dibutyltin on placental and fetal toxicity in rat
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Effect of dibutyltin on placental and fetal toxicity in rat

机译：二丁酯对大鼠胎盘胎儿胎儿毒性的影响

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摘要

In order to elucidate the effect of chorioallantoic and yolk sac placenta on the embryonic/fetal toxicity in dibutyltin dichloride (DBTC1)-exposed rats, we examined the histopathological changes and the tissue distribution of dibutyltin in the placentas and embryos. DBTC1 was orally administered to the groups at doses of 0 mg/kg during gestation days (GD)s 7-9 (control group) and 20 mg/kg during GDs 7-9 (GD7-9 treated group), and GDs 10-12 (GD10-12 treated group). The total fetal mortality was increased, and malformations characterized by craniofacial dysmolphism were detected in the GD7-9 treated group. The embryonic/fetal weight and placental weight showed a decrease in both DBTC1-treated groups. Histologically, some embryos on GD 9.5 in.the GD7-9 treated group underwent apoptosis without any changes of yolk sac. In the laser ablation-inductively coupled plasma-mass spectrometry analysis (LA-ICP-MS), tin was detected in the embryo, allantois, yolk sac, ectoplacental cone and decidual mass surrounding the conceptus on GD 9.5 in the GD7-9 treated group. Thus, it is considered that the embryo in this period is specifically sensitive to DBTC1-induced apoptosis, compared with other parts. The chorioallantoic placentas in both DBTC1-treated groups showed the developmental delay and hypoplasia in the fetal parts of placenta, resulting from apoptosis and mitotic inhibition. Thus, it was speculated that the DBTC1-induced malformations and fetal resorption resulted from the apoptosis in the embryo caused by the direct effect of DBTC1. The DBTC1-induced lesions in the chorioallantoic placenta were a non-specific transient developmental retardation in the fetal parts of placenta, leading to intrauterine growth retardation.
机译：为了阐明Chorioalantic和Yolk Sac胎盘对二丁基二氯化锡（DBTC1）的胚胎/胎儿毒性的影响（DBTC1），我们检查了胎盘和胚胎中二丁基锡的组织病理学变化和组织分布。在GDS 7-9（GD7-9处理组）和GDS 10期间，在妊娠日（GD）S 7-9（对照组）和20mg / kg期间以0mg / kg的剂量口服给予组的组。 12（GD10-12治疗组）。在GD7-9治疗组中检测到总胎儿死亡率增加，并且在GD7-9治疗组中检测到颅面渗透性畸形的畸形。胚胎/胎儿重量和胎盘重量显示DBTC1处理组的降低。组织学上，一些胚胎上GD 9.5 in.GD7-9治疗组接受了凋亡而无需任何变化的蛋黄酱。在激光烧蚀电感耦合等离子体质谱分析（La-ICP-MS）中，在GD7-9治疗组GD 9.5上围绕Gd 9.5的概念筛选锡，紫杉醇，蛋黄囊，口腔癌和蜕膜肿块。因此，与其他部分相比，该时期的胚胎对DBTC1诱导的凋亡特别敏感。 DBTC1治疗组中的诱导型胎儿胎盘在胎盘胎儿部分的发育延迟和发育性显示，由细胞凋亡和有丝分裂抑制产生。因此，据推测，DBTC1诱导的畸形和胎儿吸收是由胚胎的凋亡引起的DBTC1的直接效应引起的。 DBTC1诱导的诱导胎儿中的病变是胎盘胎儿部分的非特异性瞬态发育延迟，导致宫内生长迟缓。

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    Furukawa Satoshi; Tsuji Naho; Kobayashi Yoshiyuki; Yamagishi Yoshikazu; Hayashi Seigo; Abe Masayoshi; Kuroda Yusuke; Kimura Masayuki; Hayakawa Chisato; Sugiyama Akihiko;

  • 作者单位

    Nissan Chem Ind Co Ltd Biol Res Labs 1470 Shiraoka Shiraoka Saitama 3490294 Japan;

    Nissan Chem Ind Co Ltd Biol Res Labs 1470 Shiraoka Shiraoka Saitama 3490294 Japan;

    Nissan Chem Ind Co Ltd Chem Res Labs 2-10-1 Tsuboi Nishi Funabashi Chiba 2748507 Japan;

    Nissan Chem Ind Co Ltd Biol Res Labs 1470 Shiraoka Shiraoka Saitama 3490294 Japan;

    Nissan Chem Ind Co Ltd Biol Res Labs 1470 Shiraoka Shiraoka Saitama 3490294 Japan;

    Nissan Chem Ind Co Ltd Biol Res Labs 1470 Shiraoka Shiraoka Saitama 3490294 Japan;

    Nissan Chem Ind Co Ltd Biol Res Labs 1470 Shiraoka Shiraoka Saitama 3490294 Japan;

    Nissan Chem Ind Co Ltd Biol Res Labs 1470 Shiraoka Shiraoka Saitama 3490294 Japan;

    Nissan Chem Ind Co Ltd Biol Res Labs 1470 Shiraoka Shiraoka Saitama 3490294 Japan;

    Tottori Univ Sch Vet Med Fac Agr Courses Vet Lab Med Minami Ku 4-101 Koyama Cho Tottori;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    Dibutyltin; LA-ICP-MS; Malformation; Placenta; Rat;

    机译：二丁基锡;La-ICP-MS;畸形;胎盘;老鼠;

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